ML266
Based on 1 Customer Validation
ML266 is glucocerebrosidase (GCase) molecule chaperone with IC50 of 2.5 µM. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the activity of GCase. ML266 dose not inhibit the GCase enzyme’s action. ML266 has the potential for the research of gaucher disease.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.74%
- CAS No.: 1462267-08-8
- 화학식: C24H22BrN3O4
- 분자량:496.35
-
보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
-
HY-104038
Pariceract
-
HY-117861
ML198
-
HY-N0466
Rebaudioside A
-
HY-N1510
Kaempferol 3-O-gentiobioside
-
HY-B0089
Acarbose
-
HY-100944
Conduritol B epoxide
-
HY-N2022
Castanospermine
-
HY-B0089R
Acarbose (Standard)
-
HY-N0466R
Rebaudioside A (Standard)
-
HY-N0374
Licochalcone C
-
HY-N1510R
Kaempferol 3-O-gentiobioside (Standard)
-
HY-14829E
Afegostat D-Tartrate
Biological Activity
Chemical Information
-
CAS No. 1462267-08-8
-
Appearance Solid
-
분자량 496.35
-
화학식 C24H22BrN3O4
-
Color White to off-white
-
SMILES
O=C(NCC(N(C)C1=CC=CC=C1)=O)C2=CC=CC=C2OCC(NC3=CC=C(Br)C=C3)=O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 125 mg/mL (251.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.19 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
-
Data Sheet (275 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0147 mL | 10.0735 mL | 20.1471 mL | 50.3677 mL |
| 5 mM | 0.4029 mL | 2.0147 mL | 4.0294 mL | 10.0735 mL | |
| 10 mM | 0.2015 mL | 1.0074 mL | 2.0147 mL | 5.0368 mL | |
| 15 mM | 0.1343 mL | 0.6716 mL | 1.3431 mL | 3.3578 mL | |
| 20 mM | 0.1007 mL | 0.5037 mL | 1.0074 mL | 2.5184 mL | |
| 25 mM | 0.0806 mL | 0.4029 mL | 0.8059 mL | 2.0147 mL | |
| 30 mM | 0.0672 mL | 0.3358 mL | 0.6716 mL | 1.6789 mL | |
| 40 mM | 0.0504 mL | 0.2518 mL | 0.5037 mL | 1.2592 mL | |
| 50 mM | 0.0403 mL | 0.2015 mL | 0.4029 mL | 1.0074 mL | |
| 60 mM | 0.0336 mL | 0.1679 mL | 0.3358 mL | 0.8395 mL | |
| 80 mM | 0.0252 mL | 0.1259 mL | 0.2518 mL | 0.6296 mL | |
| 100 mM | 0.0201 mL | 0.1007 mL | 0.2015 mL | 0.5037 mL |
ML266 Related Classifications
HY-126362 Related Classifications
Powered by Bioz