MRL-650
MRL-650 (CB1 inverse agonist 1), a chemical probe, is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC50s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects.
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- CAS No.: 852315-00-5
- 화학식: C25H18Cl3N3O3
- 분자량:514.79
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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CB1 7.5 nM (IC50) |
CB2 4100 nM (IC50) |
The pharmacokinetic profile of CB1 inverse agonist 1 is evaluated in Sprague-Dawley rats, C57BL/6 mice, beagles, and rhesus macaques with t1/2 of >8, >8, >24, and 22 h, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat[1]
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Dosage:0.3, 1, or 3 mg/kg
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Administration:PO
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Result:Inhibited feeding in a dose-dependent manner. 3 mg/kg decreased cumulative food intake from 2 h post-dosing. Decreased overnight body weight gain compared to vehicle treatment at all dosing levels.
Chemical Information
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CAS No. 852315-00-5
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분자량 514.79
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화학식 C25H18Cl3N3O3
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SMILES
CC(NC1=C(C(C)=O)C(N(C)C2=NC(C3=CC=C(Cl)C=C3Cl)=C(C4=CC=C(Cl)C=C4)C=C12)=O)=O
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Synonyms
CB1 inverse agonist 1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MRL-650 Related Classifications
HY-135280 Related Classifications
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