MS-II-124
Based on 1 Customer Validation
MS-II-124 is an effective and selective NLRP3 inhibitor (IC50=0.12 μM) with anti-inflammatory and immunomodulatory activities, which can be used in the research of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.66%
- CAS No.: 3037332-85-4
- 화학식: C28H28ClFN2O4S
- 분자량:543.05
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
IC50=0.12 μM (NLRP3)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ALI/ARDS WT C57BL/6 mice model[1].
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection (i.p.), Single dose. 1 h before i.n. instillation of LPS (40 μg in 40 μL PBS).
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Result:Significantly inhibited lipopolysaccharide (LPS)-induced IL-1β production in pulmonary bronchoalveolar lavage fluid (BALF), whereas NLRP3 deletion did not significantly inhibit its production.
Chemical Information
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CAS No. 3037332-85-4
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Appearance Solid
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분자량 543.05
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화학식 C28H28ClFN2O4S
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Color White to off-white
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SMILES
ClC1=CC=C(OCCC)C(CN(CCC2=CC=C(S(=O)(NCC#C)=O)C=C2)C(C3=CC=C(F)C=C3)=O)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 35 mg/mL (64.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8415 mL | 9.2073 mL | 18.4145 mL | 46.0363 mL |
| 5 mM | 0.3683 mL | 1.8415 mL | 3.6829 mL | 9.2073 mL | |
| 10 mM | 0.1841 mL | 0.9207 mL | 1.8415 mL | 4.6036 mL | |
| 15 mM | 0.1228 mL | 0.6138 mL | 1.2276 mL | 3.0691 mL | |
| 20 mM | 0.0921 mL | 0.4604 mL | 0.9207 mL | 2.3018 mL | |
| 25 mM | 0.0737 mL | 0.3683 mL | 0.7366 mL | 1.8415 mL | |
| 30 mM | 0.0614 mL | 0.3069 mL | 0.6138 mL | 1.5345 mL | |
| 40 mM | 0.0460 mL | 0.2302 mL | 0.4604 mL | 1.1509 mL | |
| 50 mM | 0.0368 mL | 0.1841 mL | 0.3683 mL | 0.9207 mL | |
| 60 mM | 0.0307 mL | 0.1535 mL | 0.3069 mL | 0.7673 mL |
MS-II-124 Related Classifications
HY-159159 Related Classifications
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