Multi-Leu peptide
Multi-Leu peptide (ML-peptide) is a potent inhibitor of PACE4 (Ki=22 nM). Multi-Leu peptide can competitively bind to the active site of PACE4 by simulating the substrate sequence of PACE4, thereby inhibiting its catalytic activity. Multi-Leu peptide can be used to study the specific mechanism of PACE4 in the development of prostate cancer.
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- CAS No.: 1413058-07-7
- 화학식: C49H94N16O9
- 분자량:1051.37
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
100 μM
Compound: 1
|
Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
|
[PMID: 30180568] |
| DU-145 | IC50 |
100 μM
Compound: Ac-LLLLRVKR-NH2
|
Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay
|
[PMID: 23126600] |
| DU-145 | IC50 |
100 μM
Compound: ML
|
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
|
[PMID: 24350995] |
| DU-145 | IC50 |
25 μM
Compound: 1
|
Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay
|
[PMID: 30501188] |
| LNCaP | IC50 |
180 μM
Compound: 1
|
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
|
[PMID: 30180568] |
| LNCaP | IC50 |
180 μM
Compound: Ac-LLLLRVKR-NH2
|
Cytotoxicity against human LNCAP cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human LNCAP cells assessed as growth inhibition after 72 hrs by MTT assay
|
[PMID: 23126600] |
| LNCaP | IC50 |
180 μM
Compound: ML
|
Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay
Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay
|
[PMID: 24350995] |
| LNCaP | IC50 |
45 μM
Compound: 1
|
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay
|
[PMID: 30501188] |
Chemical Information
-
CAS No. 1413058-07-7
-
분자량 1051.37
-
화학식 C49H94N16O9
-
Synonyms
ML-peptide, Multi-Leucine (ML)-peptide
-
Sequence
Ac-Leu-Leu-Leu-Leu-Arg-Val-Lys-Arg-NH2
-
Sequence Shortening
Ac-LLLLRVKR-NH2
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)