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Cat. No.: HY-W839206

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NOS-IN-4

NOS-IN-4 (Compound 3) is a neuronal nitric oxide synthase (nNOS) inhibitor with an IC₅₀ of 4.00 μM that inhibits nNOS activity. The combined use of alpha-lipoic acid and NOS-IN-4 has a protective effect against MPTP (HY-W114750)-induced dopamine depletion in the mouse brain. NOS-IN-4 can be used for the research of neurological disease.

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CAS No.: 3737-39-1
화학식: C₁₁H₁₀N₂S
분자량:202.28

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

NOS-IN-4 Chemical Structure

CAS No.: 3737-39-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

nNOS

4.00 μM (IC₅₀)

All NO Synthase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	Inhibition	-6.99 % Compound: LTA	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging	10.21203/rs.3.rs-23951/v1

In Vitro

NOS-IN-4 (up to 100 µM) is inactive in protecting mouse hippocampal neuronal HT22 cells from glutamate-induced cytotoxicity^[1].
NOS-IN-4 (up to 100 µM) is inactive in preventing glutamate-induced glutathione depletion in mouse hippocampal neuronal HT22 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3737-39-1
분자량 202.28
화학식 C₁₁H₁₀N₂S
SMILES

N=C(NC=1C=CC=CC1)C=2SC=CC2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Harnett JJ, et al. Novel lipoic acid analogues that inhibit nitric oxide synthase. Bioorg Med Chem Lett. 2002;12(11):1439-1442. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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NOS-IN-4

All NO Synthase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

NOS-IN-4 Related Classifications

HY-W839206 Related Classifications