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Cat. No.: HY-184558

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NP7r

NP7r is an antioxidant and neuroprotective agent. NP7r regulates oxidative stress, upregulates downstream antioxidant genes, reduces mitochondrial ROS, initiates Autophagy and clears α-synuclein aggregates. NP7r alleviates dopaminergic neuron degeneration, restores fat content, reduces lipid peroxidation, and improves motor impairment and abnormal food perception. NP7r is applicable to the research of Parkinson's disease.

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CAS No.: 2641092-28-4
화학식: C₂₆H₂₀O₃
분자량:380.44

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NP7r Chemical Structure

CAS No.: 2641092-28-4

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All α-synuclein Isoforms :

In Vivo

NP7r (10-80 μM; 48 h) exerts neuroprotective effects in an α-synuclein-expressing C. elegans Parkinson's disease model, with mechanisms involving a statistically significant reduction in mitochondrial ROS levels, approximately 30% decrease in α-synuclein aggregation, and upregulation of antioxidant and autophagy-related pathways^[1].
NP7r (10 μM) protects *Caenorhabditis elegans* against 6-OHDA (HY-B1081)-induced dopaminergic neuron degeneration, restoring the total fluorescence intensity of dopaminergic neurons to 96.28% of that in the control group^[1].
NP7r (10 μM) alleviates 6-OHDA-induced growth and behavioral defects in wild-type *Caenorhabditis elegans*, restoring its movement and feeding-related behaviors to levels close to those of the control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NL5901 pkIs2386 [unc-54p::alpha-synuclein:YFP + unc-119(+)]^[1]
Dosage:

10 μM; 20 μM; 40 μM; 80 μM
Administration:

nematode growth medium; 48 hours
Result:

Significantly reduced mitochondrial ROS levels in NL5901 worms (effect dependent on skn-1 gene).
Decreased α-synuclein-YFP fluorescence intensity by ~30% relative to untreated controls.
Reduced MDA levels and partially restored lipid droplet area in NL5901 worms.
Upregulated mRNA levels of skn-1, gst-4, gcs-1, cct-2, cct-3, cct-4, cct-6, cct-7, cct-8, lgg-1, unc-51, epg-5, epg-8, vps-35, and atg-7.
Downregulated daf-16 and sod-3 mRNA levels.
Increased GSH levels and restored GST-4::GFP fluorescence intensity in 6-OHDA-treated CL2166 worms.
Confirmed α-synuclein clearance effect dependent on cct-6, lgg-1, and unc-51 genes.

Animal Model:

BZ555 egls1[Pdat-1::gfp]^[1]
Dosage:

10 μM
Administration:

nematode growth medium; post-6-OHDA exposure
Result:

Restored total dopaminergic neuron fluorescence intensity to 96.28% of untreated BZ555 levels, representing a 36.23% increase relative to 6-OHDA-only treated worms.
Restored fluorescence intensity of cephalic (CEP), anterior deirid (ADE), and posterior deirid (PDE) dopaminergic neurons.

Animal Model:

N2^[1]
Dosage:

10 μM
Administration:

nematode growth medium; post-6-OHDA exposure
Result:

Restored 6-OHDA-reduced body length, tail thrashing frequency, slowing rate, travel distance, velocity, and body bend frequency in N2 worms to levels statistically comparable to untreated controls.

Chemical Information

CAS No. 2641092-28-4
분자량 380.44
화학식 C₂₆H₂₀O₃
SMILES

O=C1CCC2=C1C(C3=CC=CC=C3)=CC(C4=CC=C(C=C4)O)(O2)C5=CC=CC=C5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Han RT, et al. Pyran compound 7r exerts neuroprotective effects against Parkinson's disease via modulating oxidative stress and autophagy. iScience. 2026 Jun 8;29(6):116233. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vivo
Chemical Information
순도&문서
References

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NP7r

All α-synuclein Isoforms