NSC804515
NSC804515 is an inhibitor of wild-type and R155H mutant p97/VCP ATPase, with an IC50 of about 15 nM for both targets. NSC804515 acts as an antiproliferative agent, disrupts the function of the ubiquitin-proteasome system, induces UbG76V-GFP accumulation, and shows reduced inhibitory potency against p97 variants carrying P510S, K512N, N616F and F618S mutations. NSC804515 can be used in research related to cancer, inclusion body myopathy with early-onset Paget's disease and frontotemporal dementia, as well as familial amyotrophic lateral sclerosis.
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- 화학식: C26H25F2N5O2S
- 분자량:509.57
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
NSC804515 exhibits drastically reduced inhibitory potency against purified human p97 resistance mutants p97P510S, p97N616F, and p97F618S (over 30-fold higher IC50) and p97K512N (12-fold higher IC50) compared to wild-type p97[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 509.57
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화학식 C26H25F2N5O2S
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SMILES
FC1=CC(OCC2=NN=C(S[C@H]3C=CCCC3)N2C4=CN=CC=C4)=C(F)C=C1C#CCNC(CC)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NSC804515 Related Classifications
HY-168007 Related Classifications
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Keywords
- NSC804515
- NSC 804515
- NSC-804515
- p97
- p97R155H
- R155H mutant human p97/VCP ATPase
- cancer
- UbG76V-GFP
- p97WT
- inclusion body myopathy with early-onset paget disease and frontotemporal dementia
- familial amyotrophic lateral sclerosis
- ubiquitin-proteasome system
- human p97/VCP ATPase
- D1-D2 domain interface
- Inhibitor
- inhibitor
- inhibit