OGT-719
OGT-719 is a potent, orally active nucleoside analogue that targets the asialoglycoprotein receptor (ASGP-R). OGT-719 inhibits growth of metastatic colorectal tumors in the liver of nude mice. OGT-719 can be used for primary hepatocellular carcinoma and colorectal liver metastases research.
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- CAS No.: 185843-61-2
- 화학식: C10H13FN2O7
- 분자량:292.22
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
OGT-719 (80 mM, 4 h) inhibits thymidylate synthase (TS) activity in C170HM2 cells at a concentration of 80 mM (approximately 2xIC50)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male MFI nude mice injected with C170HM2 cells into the peritoneal cavity[1]
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Dosage:1500 mg/kg/day
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Administration:p.o., b.i.d. for 32 days
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Result:Showed a significant 70% reduction in mean liver tumor burden.
Showed a significant decrease in mean liver tumor cross-sectional areas.
Showed no significant effect on animal weight.
Chemical Information
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CAS No. 185843-61-2
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분자량 292.22
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화학식 C10H13FN2O7
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SMILES
O=C1NC(C(F)=CN1[C@H]2[C@@H]([C@H]([C@H]([C@@H](CO)O2)O)O)O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OGT-719 Related Classifications
HY-19272 Related Classifications
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