Ontorpacept
Based on 1 publication(s) in Google Scholar
Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPα N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a CD47-blocking checkpoint inhibitor with antitumor activity.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.57%
- CAS No.: 2131089-46-6
- 분자량:76.43 kDa
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ontorpacept
More
Biological Activity
제품 설명
In Vitro
Ontorpacept (0.001-1000 nmol/L; 2 h) dose-dependently increases macrophage phagocytosis of tumor cells with an average EC50 of 10 nmol/L in primary samples from patients with AML, MDS, multiple myeloma, B-ALL, and T-ALL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD.SCID mice with AML cell transplants[1]
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Dosage:8 mg/kg
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Administration:Intraperitoneal injection; 8 mg/kg, 3 times a week for 4 weeks
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Result:Significantly reduced the tumor growth in bone marrow and spleen.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Homo sapiens SIRPA (signal regulatory protein alpha, SHPS1, SIRP, SIRPalpha)-IGHG1 (Fc (Fragment constant)
신청
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized Ontorpacept can bind Human CD47 Protein (ECD, His Tag). The EC50 for this effect is 9.12 ng/mL.
Chemical Information
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CAS No. 2131089-46-6
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Appearance Liquid
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분자량 76.43 kDa
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Color Colorless to light yellow
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SMILES
[Ontorpacept]
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Synonyms
TTI-621
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Transfusion
Anti-CD47 drug interference in pre-transfusion testing can be overcome by antigen masking. [Abstract]2025 Aug 13. PMID: 40799186
순도&문서
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ontorpacept Related Classifications
HY-P99777 Related Classifications
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