PDE2A-IN-2
PDE2A-IN-2 is a selective and brain-penetrant PDE2A inhibitor (Ki = 5.49 nM and 100 > fold selectivity over other PDE isoforms). The 11C-labeled PDE2A-IN-2 serves as a positron emission tomography (PET) tracer for brain imaging in patients with neurodegenerative diseases. PDE2A-IN-2 educes the radiotracer signal in PDE2A-rich regions in vitro. PDE2A-IN-2 exhibits low binding affinity in vivo. PDE2A-IN-2 can be used for neurodegenerative diseases .
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- CAS No.: 2055901-03-4
- 화학식: C17H16F3N5
- 분자량:347.34
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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PDE2A 5.49 nM (Ki) |
PDE2A-IN-2 (compound 1) (1 μM, 30 min) reduces the radiotracer signal in PDE2A-rich regions, leading to a more homogeneous distribution in SD rat brain sections when co-treated with its unlabeled form (1 μM) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SD rat[1]
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Dosage:1 mg/kg
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Administration:i.v., once
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Result:Led to similar TAC patterns and regional brain distributions to baseline.
Chemical Information
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CAS No. 2055901-03-4
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분자량 347.34
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화학식 C17H16F3N5
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SMILES
CC1=NC2=C(C(NC3(C4=CC=C(C=C4)C(F)(F)F)CC3)=N1)C=NN2C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDE2A-IN-2 Related Classifications
HY-180526 Related Classifications
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