PG-931
Based on 1 Customer Validation
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.60%
- CAS No.: 667430-81-1
- 화학식: C59H85N15O11
- 분자량:1180.40
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보관:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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MC4R |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats[2]
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Dosage:13-108 nmol/kg
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Administration:Intravenous injection; single dose
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Result:Exhibitd an anti-shock effect occurred at nanomolar doses.
Chemical Information
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CAS No. 667430-81-1
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Appearance Solid
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분자량 1180.40
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화학식 C59H85N15O11
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Color White to off-white
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Sequence
Ac-{Nle}-Asp-Pro-{d-Phe}-Arg-Trp-Lys-Pro-Val-NH2 (Lactam bridge: Asp2-Lys7)
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Sequence Shortening
Ac-{Nle}-DP-{d-Phe}-RWKPV-NH2 (Lactam bridge: Asp2-Lys7)
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
용액&용해도
H2O : 100 mg/mL (84.72 mM; Need ultrasonic)
DMSO : ≥ 100 mg/mL (84.72 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. D Giuliani, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol [Content Brief]
[2]. P Grieco, et al. Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. J Pept Res [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.8472 mL | 4.2359 mL | 8.4717 mL | 21.1793 mL |
| 5 mM | 0.1694 mL | 0.8472 mL | 1.6943 mL | 4.2359 mL | |
| 10 mM | 0.0847 mL | 0.4236 mL | 0.8472 mL | 2.1179 mL | |
| 15 mM | 0.0565 mL | 0.2824 mL | 0.5648 mL | 1.4120 mL | |
| 20 mM | 0.0424 mL | 0.2118 mL | 0.4236 mL | 1.0590 mL | |
| 25 mM | 0.0339 mL | 0.1694 mL | 0.3389 mL | 0.8472 mL | |
| 30 mM | 0.0282 mL | 0.1412 mL | 0.2824 mL | 0.7060 mL | |
| 40 mM | 0.0212 mL | 0.1059 mL | 0.2118 mL | 0.5295 mL | |
| 50 mM | 0.0169 mL | 0.0847 mL | 0.1694 mL | 0.4236 mL | |
| 60 mM | 0.0141 mL | 0.0706 mL | 0.1412 mL | 0.3530 mL | |
| 80 mM | 0.0106 mL | 0.0529 mL | 0.1059 mL | 0.2647 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PG-931 Related Classifications
HY-P1208 Related Classifications
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