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Cat. No.: HY-184893

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PSH18

PSH18 is a selective monoamine oxidase B (MAO-B) inhibitor with blood-brain barrier permeability, with a human-derived IC₅₀ of 0.95 μM and a K_i of 0.89 μM. PSH18 can be used for the research of Parkinson's disease.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₁₈H₁₃FN₄OS
분자량:352.39

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

PSH18 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

hMAO-B

0.95 μM (IC₅₀)

hMAO-B

0.89 μM (Ki)

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

In Vitro

PSH18 competes with substrates for binding to the active site of MAO-B, and forms stable active site interactions through hydrophobic interactions and π-π stacking^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 352.39
화학식 C₁₈H₁₃FN₄OS
SMILES

S=C(N/N=C1C(N(CC#C)C2=C\1C=C(F)C=C2)=O)NC3=CC=CC=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Parmbil SK, et al. Synthesis, biological evaluation and in silico studies of novel propargyl-tethered isatin hydrazones as monoamine oxidase inhibitors for Parkinson's disease. Scientific reports. 2026 Jun 19. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

PSH18

All Monoamine Oxidase Isoforms