PZ-1657
PZ-1657 (Compound 57) is an orally active, blood-brain barrier permeable, highly selective, and metabolically stable 5-HT7 receptor inverse agonist with a Ki value of 5 nM. PZ-1657 inhibits constitutive cyclic adenosine monophosphate (cAMP) production mediated by the Gs signaling pathway (EC50 value of 2.93 nM). PZ-1657 inhibits CYP3A4 P450 (IC50 = 12.2 μM) and hERG channels. PZ-1657 reduces 5-HT7 receptor-mediated MMP-9 activity. PZ-1657 reverses Phencyclidine-induced cognitive impairment. PZ-1657 possesses antidepressant properties.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C23H27FN4O3S
- 분자량:458.55
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
|
MMP-9 |
5-HT7 Receptor 5 nM (Ki) |
5-HT1A Receptor 292 nM (Ki) |
D2 Receptor 1004 nM (Ki) |
CYP3A4 12.2 μM (IC50) |
Chemical Information
-
분자량 458.55
-
화학식 C23H27FN4O3S
-
SMILES
O=S(C1=CC=C(F)C=C1)(NC2CCN(CCOC3=CC=CC=C3C4=CN(C)N=C4)CC2)=O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PZ-1657 Related Classifications
HY-179724 Related Classifications
Powered by Bioz