QP5

QP5 (25 μM) binds strongly and stably to demineralized human tooth enamel, with greater binding compared to sound enamel^[1].
QP5 (200 μM; 30 min, 2 h, 24 h) transiently stabilizes ACP and directs its transformation into HA crystals with a natural enamel-matching Ca²⁺/P ratio of 1.67; when combined with fluoride, it directs formation of elongated rod-like HA/FHA crystals^[1].
QP5 (25 μM; four times daily for 5 min each, over 12 days) alone promotes remineralization of artificial human enamel caries with effects similar to fluoride, and when combined with fluoride, it exerts a synergistic effect that significantly enhances surface microhardness recovery, reduces mineral loss and lesion depth, and increases mineral content compared to either treatment alone^[1].
QP5 (600 μM; 2 h) adsorbs on nucleated minerals in solution via its functional domains, stabilizes amorphous calcium phosphate, and inhibits spontaneous nucleation of crystalline HAP after 2 hours of incubation^[2].
QP5 (200 μM; 30 min pre-coating, 14 days treatment) promotes biomimetic remineralization of demineralized bovine enamel, achieving a surface microhardness recovery of 72.07%^[2].
QP5 (100 ns; 310 K) stably adsorbs to the HAP (001) surface via negatively charged C-tail domain residues (Glu19, Glu20, Asp22) through electrostatic interactions, then recruits Ca²⁺ from solution to promote enamel biomimetic remineralization during 100 ns molecular dynamics simulation at 310 K^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.