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Cat. No.: HY-181498

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RAFKBP12

RAFKBP12 is a FKBP12 CAP-TAC (proteinase complex cap-targeted chimera) degrader. RAFKBP12 demonstrates the feasibility of the CAP-TAC strategy, which enables proteasome-dependent degradation of FKBP12 that is independent of E3 ubiquitin ligases and protein ubiquitination.
(Pink: FKBP12 ligand (HY-114434); Blue: Proteasome ligand (HY-181499); Black: linker).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2375455-59-5
화학식: C₇₉H₉₃Cl₄N₅O₁₇
분자량:1526.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

RAFKBP12 Chemical Structure

CAS No.: 2375455-59-5

사이즈

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

RAFKBP12 is a FKBP12 CAP-TAC (proteinase complex cap-targeted chimera) degrader. RAFKBP12 demonstrates the feasibility of the CAP-TAC strategy, which enables proteasome-dependent degradation of FKBP12 that is independent of E3 ubiquitin ligases and protein ubiquitination^[1]. (Pink: FKBP12 ligand (HY-114434); Blue: Proteasome ligand (HY-181499); Black: linker).

In Vitro

RAFKBP12 (1-10 μM; 24 h) induces degradation of FKBP12 in HEK293T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HEK293T cells
Concentration:

1, 2.5, 10 μM
Incubation Time:

24 h
Result:

Induced degradation of FKBP12 in HEK293T cells, as detected by western blotting.

Chemical Information

CAS No. 2375455-59-5
분자량 1526.42
화학식 C₇₉H₉₃Cl₄N₅O₁₇
SMILES

O=C([C@@H]1CCCCN1C([C@@H](CC)C2=CC(OC)=C(OC)C(OC)=C2)=O)O[C@@H](C3=CC=CC(OCC(NCCOCCOCCOCCC(NCCOCCN[C@H](C(N4C/C(C(/C(C4)=C/C5=CC(Cl)=C(Cl)C=C5)=O)=C\C6=CC=C(Cl)C(Cl)=C6)=O)CC7=CC=CC=C7)=O)=O)=C3)CCC8=CC(OC)=C(OC)C=C8
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Song C, et al. Proteasome Cap Targeting Chimeras for Ubiquitination-Independent Targeted Protein Degradation. Angew Chem Int Ed Engl. 2026;65(9):e20039. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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