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Cat. No.: HY-124368

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RB-042

RB-042 is a SK1 and SK2 inhibitor with IC₅₀ values of 5.3 μM and 5.0 μM, respectively. RB-042 is applicable to the research of inflammatory diseases.

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CAS No.: 1491909-40-0
화학식: C₂₅H₄₃NO
분자량:373.63

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

RB-042 Chemical Structure

CAS No.: 1491909-40-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

RB-042 is a SK1 and SK2 inhibitor with IC₅₀ values of 5.3 μM and 5.0 μM, respectively. RB-042 is applicable to the research of inflammatory diseases^[1]^[2].

IC₅₀ & Target^[1]

SphK1

5.3 μM (IC₅₀)

SphK2

5.0 μM (IC₅₀)

All SphK Isoforms :

SphK1
SphK2

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	5.3 μM Compound: RB-042	Inhibition of recombinant sphingosine kinase 1 (unknown origin) expressed in HEK293 cells using sphingosine as substrate after 30 mins in presence of [gamma32P]-ATP Inhibition of recombinant sphingosine kinase 1 (unknown origin) expressed in HEK293 cells using sphingosine as substrate after 30 mins in presence of [gamma32P]-ATP	[PMID: 24164513]

In Vitro

RB-042 is an equipotent inhibitor of sphingosine kinase 1 and sphingosine kinase 2, with an IC₅₀ value of 5.3 μM against SK1 and 5.0 μM against SK2^[1].
RB-042 binds to the catalytic site of sphingosine kinase 1 via polar interactions with residues D178, D81, and L268^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1491909-40-0
분자량 373.63
화학식 C₂₅H₄₃NO
SMILES

C(CC1=CC=C(CCCCCCCCCCCC)C=C1)N2[C@@H](CO)CCC2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Baek DJ, et al. Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors. J Med Chem. 2013;56(22):9310-9327. [Content Brief]

[2]. Shrestha J, et al. Synthesis of Novel FTY720 Analogs with Anticancer Activity through PP2A Activation. Molecules. 2018;23(11):2750. Published 2018 Oct 24. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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RB-042

All SphK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

RB-042 Related Classifications

HY-124368 Related Classifications