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Cat. No.: HY-163384

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(S)-CE-123

(S)-CE-123 is a potent, selective, and novel atypical dopamine transporter (DAT) inhibitor with an EC₅₀ of 2.76 μM in uptake inhibition assays conducted in HEK293 cells stably expressing human isoforms of DAT. (S)-CE-123, a Modafinil analogue, is able to penetrate the blood–brain barrier. (S)-CE-123 improves cognitive and motivational processes in experimental animals.

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CAS No.: 2378384-49-5
화학식: C₁₇H₁₅NOS₂
분자량:313.44

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

(S)-CE-123 Chemical Structure

CAS No.: 2378384-49-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

In Vivo

(S)-CE-123 (6.0, 12.0, 24.0 mg/kg; ip; 30 min before testing) significantly attenuates the effects of TBZ (Tetrabenazine; HY-B0590) on lever pressing and chow intake. (S)-CE-123 alone has no significant difference with vehicle-treated rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Trained rats (adult male Sprague-Dawley rats)^[1]
Dosage:

6.0, 12.0, 24.0 mg/kg
Administration:

IP; 30 min before testing
Result:

Attenuated the effects of TBZ (1.0 mg/kg) on lever pressing and chow intake.

Chemical Information

CAS No. 2378384-49-5
분자량 313.44
화학식 C₁₇H₁₅NOS₂
SMILES

O=[S@@](CC1=CN=CS1)C(C2=CC=CC=C2)C3=CC=CC=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

용액&용해도

View the Complete Stock Solution Preparation Table

In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

Protocol 1

10% DMSO +15%Tween 80 +75% 0.9% saline

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Renee A Rotolo, et al. The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding. Front Pharmacol. 2019 Jun 28:10:682. [Content Brief]

[2]. Eduardo R. Perez Gonzalez, et al. Process Development and Scale-Up of a Novel Atypical DAT Inhibitor (S)-CE-123. ACS Omega 2024, March 4.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- In Vivo
Chemical Information
용액&용해도
- In Vivo
순도&문서
References

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(S)-CE-123

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