(S)-MCOPPB
Based on 1 Customer Validation
(S)-MCOPPB is the S-form of MCOPPB (HY-13101). MCOPPB is an orally active and selective agonist of Nociceptin/Orphanin FQ-Receptor. MCOPPB inhibits signaling through the NOP receptor in the mouse brain. MCOPPB can be used for anxiety disorders study.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.97%
- CAS No.: 1108147-70-1
- 화학식: C26H40N4
- 분자량:408.62
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Membrane Receptor-targeted Compound Library
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Highly Selective Activators Library
HY-L159
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Lactylation Compound Library
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All Opioid Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | EC50 |
23 nM
Compound: 21
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Agonist activity at human mu opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS binding
Agonist activity at human mu opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS binding
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[PMID: 19125610] |
| CHO-K1 | EC50 |
514 nM
Compound: 21
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Agonist activity at human delta opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS binding
Agonist activity at human delta opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS binding
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[PMID: 19125610] |
| HEK293 | EC50 |
0.5 nM
Compound: 21
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Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS binding
Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS binding
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[PMID: 19125610] |
| HEK293 | EC50 |
8.4 nM
Compound: 21
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Agonist activity at human kappa opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding
Agonist activity at human kappa opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding
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[PMID: 19125610] |
Chemical Information
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CAS No. 1108147-70-1
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Appearance Solid
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분자량 408.62
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화학식 C26H40N4
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Color White to off-white
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SMILES
CC1(CCCCCCC1)N2CCC(CC2)N3C([C@H]4CCCNC4)=NC5=CC=CC=C53
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
DMSO : 5 mg/mL (12.24 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Hayashi S, et al. Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drug. J Med Chem. 2009 Feb 12;52(3):610-25. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4473 mL | 12.2363 mL | 24.4726 mL | 61.1815 mL |
| 5 mM | 0.4895 mL | 2.4473 mL | 4.8945 mL | 12.2363 mL | |
| 10 mM | 0.2447 mL | 1.2236 mL | 2.4473 mL | 6.1182 mL |
(S)-MCOPPB Related Classifications
HY-13101B Related Classifications
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