(S)-Thalidomide 4-fluoride
Based on 1 Customer Validation
(S)-Thalidomide 4-fluoride is a CRBN E3 ligase ligand that can be used for synthesis of DeDPP4 (HY-182336).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 911109-85-8
- 화학식: C13H9FN2O4
- 분자량:276.22
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
Cereblon |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 911109-85-8
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Appearance Solid
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분자량 276.22
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화학식 C13H9FN2O4
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Color White to off-white
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SMILES
O=C1N([C@@H](CC2)C(NC2=O)=O)C(C3=C1C=CC=C3F)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 66.67 mg/mL (241.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6203 mL | 18.1015 mL | 36.2030 mL | 90.5076 mL |
| 5 mM | 0.7241 mL | 3.6203 mL | 7.2406 mL | 18.1015 mL | |
| 10 mM | 0.3620 mL | 1.8102 mL | 3.6203 mL | 9.0508 mL | |
| 15 mM | 0.2414 mL | 1.2068 mL | 2.4135 mL | 6.0338 mL | |
| 20 mM | 0.1810 mL | 0.9051 mL | 1.8102 mL | 4.5254 mL | |
| 25 mM | 0.1448 mL | 0.7241 mL | 1.4481 mL | 3.6203 mL | |
| 30 mM | 0.1207 mL | 0.6034 mL | 1.2068 mL | 3.0169 mL | |
| 40 mM | 0.0905 mL | 0.4525 mL | 0.9051 mL | 2.2627 mL | |
| 50 mM | 0.0724 mL | 0.3620 mL | 0.7241 mL | 1.8102 mL | |
| 60 mM | 0.0603 mL | 0.3017 mL | 0.6034 mL | 1.5085 mL | |
| 80 mM | 0.0453 mL | 0.2263 mL | 0.4525 mL | 1.1313 mL | |
| 100 mM | 0.0362 mL | 0.1810 mL | 0.3620 mL | 0.9051 mL |
(S)-Thalidomide 4-fluoride Related Classifications
HY-W763812 Related Classifications
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