country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182416

Copy Link Print Information

slCeMM1

slCeMM1 is a selective SLC16A3 (MCT4) inhibitor. slCeMM1 inhibits lactate transport, induces intracellular lactate accumulation, reduces viability of SLC16A3-dependent cells, and inhibits growth of SLC16A3-dependent cells. slCeMM1 can be used for the research of rheumatoid arthritis and cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 949973-22-2
화학식: C₂₀H₁₇F₃N₆O
분자량:414.38

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

slCeMM1 Chemical Structure

CAS No.: 949973-22-2

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

MCT4

All Monocarboxylate Transporter Isoforms :

In Vitro

slCeMM1 (serial dilutions; 72 h) potently and selectively inhibits viability of SLC16A3-dependent HAP1 SLC16A1^-/- cells with an IC₅₀ of 0.88 μM, while having no effect on HAP1 cells dependent on SLC16A1, SLC16A7, or SLC16A8^[1].
slCeMM1 (serial dilutions; 6 h) induces intracellular lactate accumulation in SLC16A3-dependent HAP1 SLC16A1^-/- cells with an IC₅₀ of 91 nM, confirming inhibition of SLC16A3-mediated lactate export^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 949973-22-2
분자량 414.38
화학식 C₂₀H₁₇F₃N₆O
SMILES

O=C(CCC1=C(C)N2N=C(C(F)(F)F)N=C2N=C1C)NC3=CN=C4C=CC=CC4=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Dvorak V, et al. Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors. Cell Chem Biol. 2023;30(8):953-964.e9. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

slCeMM1

High-Throughput Bioactive Compound Library

All Monocarboxylate Transporter Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

slCeMM1 Related Classifications

HY-182416 Related Classifications