SS-RJW100
Based on 1 Customer Validation
SS-RJW100 is a enantiomer of RJW100, which is a racemic agonist of nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). SS-RJW100 promotes recruitment of coregulator protein fragments in vitro, recruits the transcriptional intermediary factor 2 (Tif2) coactivator to LRH-1. SS-RJW100 diminishes LRH-1 allosteric activation networks, shows poor thermal stability.
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- Purity: 99.91%
- 화학식: C28H34O
- 분자량:386.57
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보관:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Ki: 1.2 μM (LRH-1), 30 μM (SF-1)[1]
Liver receptor homolog-1 (LRH-1) and steroidogenic factor-1 (SF-1) are closely related nuclear hormone receptors (NR) that play key roles as regulators of metabolism, inflammation, and proliferation[1].
SS-RJW100 (1 nM-1 mM; ) binds LRH-1 and SF-1, with binding affinity Ki values of 1.2 μM (LRH-1), 30 μM (SF-1), respectively[1].
SS-RJW100 (30 μM; 24 h) increases LRH-1 transcriptional activity in both wild-type and mutant LRH-1 overexpressed Hela cells, without being affected by mutations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Wild-type (WT) and mutant LRH-1 overexpressed Hela cells (T352V, H390A, A349F)
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Concentration:30 μM
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Incubation Time:24 hours; for pre-treatment
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Result:Increased increases LRH-1 transcriptional activity.
Showed activation effect on LRH-1 expressing cells without being affected by T352V LRH-1 mutant or H390A LRH-1 mutant.
Chemical Information
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Appearance Liquid (Density: 1.064±0.06 g/cm3)
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분자량 386.57
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화학식 C28H34O
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Color Colorless to light yellow
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SMILES
O[C@H]1CC[C@]2(C(C3=CC=CC=C3)=C)C(C4=CC=CC=C4)=C(CCCCCC)C[C@]12[H]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (258.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5869 mL | 12.9343 mL | 25.8685 mL | 64.6713 mL |
| 5 mM | 0.5174 mL | 2.5869 mL | 5.1737 mL | 12.9343 mL | |
| 10 mM | 0.2587 mL | 1.2934 mL | 2.5869 mL | 6.4671 mL | |
| 15 mM | 0.1725 mL | 0.8623 mL | 1.7246 mL | 4.3114 mL | |
| 20 mM | 0.1293 mL | 0.6467 mL | 1.2934 mL | 3.2336 mL | |
| 25 mM | 0.1035 mL | 0.5174 mL | 1.0347 mL | 2.5869 mL | |
| 30 mM | 0.0862 mL | 0.4311 mL | 0.8623 mL | 2.1557 mL | |
| 40 mM | 0.0647 mL | 0.3234 mL | 0.6467 mL | 1.6168 mL | |
| 50 mM | 0.0517 mL | 0.2587 mL | 0.5174 mL | 1.2934 mL | |
| 60 mM | 0.0431 mL | 0.2156 mL | 0.4311 mL | 1.0779 mL | |
| 80 mM | 0.0323 mL | 0.1617 mL | 0.3234 mL | 0.8084 mL | |
| 100 mM | 0.0259 mL | 0.1293 mL | 0.2587 mL | 0.6467 mL |
SS-RJW100 Related Classifications
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