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Cat. No.: HY-N8470

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Steffimycin B

(Synonyms: NSC 204855; U 40615)

Steffimycin B is an anthracycline bacterial metabolite originally isolated from Streptomyces. It binds to DNA, preferentially intercalating at sites containing cytosine and guanine.2 Steffimycin B is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC₅₀s=3.5, 6.75, 3.28, and 10.5 μM, respectively). It is active against M. tuberculosis (MIC=5.2 nM), B. cereus (MIC=1.56 μg/mL), and P. falciparum (IC₅₀=2.19 μM).

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CAS No.: 54526-94-2
화학식: C₂₉H₃₂O₁₃
분자량:588.56

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Steffimycin B Chemical Structure

CAS No.: 54526-94-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.8 μM Compound: 9	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay	[PMID: 38412432]
PC-3	IC₅₀	3.1 μM Compound: 9	Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by alamar blue assay	[PMID: 38412432]

Chemical Information

CAS No. 54526-94-2
분자량 588.56
화학식 C₂₉H₃₂O₁₃
SMILES

OC1=C(C(C2=C3O)=O)C(C(C2=CC(OC)=C3)=O)=CC(C4=O)=C1[C@H]([C@@H]([C@](O)4C)OC)O[C@H](O[C@H]5C)[C@@H]([C@@H]([C@H]5OC)O)OC
Synonyms

NSC 204855; U 40615
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Trenado-Uribe, et al. Antimycobacterial activity of an anthracycline produced by an endophyte isolated from Amphipterygium adstringens. Mol. Biol. Rep. 45(6), 2563-2570 (2018).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
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Steffimycin B

Albendazole-d7

Amiprofos methyl

2-epi-Abamectin

Artemether-d3

Nocardamine

Butyrolactone V

Voacangine

Thiocarlide

Carbazomycin B

Amiprofos methyl (Standard)

3-Keto fusidic acid

Trypacidin

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Steffimycin B

Albendazole-d7

Amiprofos methyl

2-epi-Abamectin

Artemether-d3

Nocardamine

Butyrolactone V

Voacangine

Thiocarlide

Carbazomycin B

Amiprofos methyl (Standard)

3-Keto fusidic acid

Trypacidin

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Steffimycin B Related Classifications

HY-N8470 Related Classifications