STL001
Based on 1 Customer Validation
STL001 is potent and selective FOXM1 inhibitor. STL001 induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation. STL001 sensitizes human cancers to a broad-spectrum of cancer therapies.
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- Purity: 99.81%
- CAS No.: 3047493-70-6
- 화학식: C27H23N7O4
- 분자량:509.52
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Autophagy Compound Library
HY-L029
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Transcription Factor-Targeted Library
HY-L090
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Highly Selective Inhibitors Library
HY-L158
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Highly Selective Activators Library
HY-L159
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
STL001 (1-10 μM; 24 h) causes a dose-dependent reduction of the cellular levels of FOXM1 protein[1].
STL001 (5 μM; 24 h) induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:OVCAR-8, ES-2, HCT-116, HCT-FET, FLO-1, TAM-R, HCC-1143, 22Rv1, LNCaP
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Concentration:1 μM, 5 μM, and 10 μM
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Incubation Time:24 h
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Result:Significantly reduced the cellular levels of FOXM1 protein.
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Cell Line:U2OS-C3-luc cells
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Concentration:5 μM
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Incubation Time:24 h
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Result:Resulted in reduced FOXM1 levels with increased expression of autophagy marker protein LC3.
Chemical Information
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CAS No. 3047493-70-6
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Appearance Solid
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분자량 509.52
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화학식 C27H23N7O4
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Color White to off-white
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SMILES
O=C(C1=CC=CO1)OC2=CC(C3=NN(C=C3)C4=NC(NC5=CC=CC=C5)=NC(N6CCOCC6)=N4)=CC=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 5 mg/mL (9.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9626 mL | 9.8132 mL | 19.6263 mL | 49.0658 mL |
| 5 mM | 0.3925 mL | 1.9626 mL | 3.9253 mL | 9.8132 mL |
STL001 Related Classifications
HY-158420 Related Classifications
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