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Cat. No.: HY-123789

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T5342126

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC₅₀=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC₅₀s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.1%
CAS No.: 956507-49-6
화학식: C₂₅H₃₂ClN₃O₃
분자량:457.99

보관:

Solution, -20°C, 2 years

T5342126 Chemical Structure

CAS No.: 956507-49-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
Publications (1)
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Bioz

Biological Activity

제품 설명

All Toll-like Receptor (TLR) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	27.8 μM Compound: 1j	Inhibition of LPS-induced TLR4 activation in mouse RAW264.7 cells assessed as reduction in NO production after 18 to 24 hrs Inhibition of LPS-induced TLR4 activation in mouse RAW264.7 cells assessed as reduction in NO production after 18 to 24 hrs	[PMID: 21591694]

Chemical Information

CAS No. 956507-49-6
Appearance Liquid
분자량 457.99
화학식 C₂₅H₃₂ClN₃O₃
Color Colorless to light yellow
SMILES

OC(COC1=CC=C(OCC)C=C1)CN(CC2=C(C)N(CC3=CC=CC=C3Cl)N=C2C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Solution, -20°C, 2 years

Publications (1)

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Environ Sci Technol

Mechanisms Underlying the Size-Dependent Neurotoxicity of Polystyrene Nanoplastics in Zebrafish. [Abstract]

2025 Jan 28;59(3):1577-1586. PMID: 39817745

순도&문서

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chavez, et al. Development of β-amino alcohol derivatives that inhibit toll-like receptor 4 mediated inflammatory response as potential antiseptics. J. Med. Chem. 54(13), 4659-4669 (2011).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
Chemical Information
Publications (1)
순도&문서
References

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T5342126

Publications Citing Use of MedChemExpress (MCE) T5342126

All Toll-like Receptor (TLR) Isoforms