Tegeprotafib
Based on 1 Customer Validation
Tegeprotafib (PTPN2/1-IN-1) (Compound 124) is an orally active PTPN1 and PTPN2 inhibitor with IC50s of 4.4 nM and 1-10 nM against PTPN2 and PTP1B, respectively.
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- Purity: 99.30%
- CAS No.: 2407610-46-0
- 화학식: C13H11FN2O5S
- 분자량:326.30
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보관:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
IC50: 4.4 nM (PTPN2), 1-10 nM (PTP1B)[1]
Tegeprotafib (Compound 124; 5 days) inhibits IFNγ (0.5 ng/mL) induced B16F10 cellular growth with a percent growth inhibition of 60-90% at 33 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female C57B1/6 mice, MC-38 tumor model[1]
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Dosage:300 mg/kg/dose
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Administration:Oral, twice a day (BID) at 7am and 5pm for 21 days
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Result:Within 7-10 days of treatment, apparent tumor stasis and shrinkage was observed. 50% of mice achieved complete cures, and an overall TGIMEX was 75%. The frequency of functional, granzyme B (GzB) producing cells within the cytotoxic CD8+ T population in the spleen was 2.9-fold increased over vehicle control treated animals. Increased IP10 levels in plasma.
Chemical Information
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CAS No. 2407610-46-0
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Appearance Solid
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분자량 326.30
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화학식 C13H11FN2O5S
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Color White to off-white
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SMILES
O=C1NS(=O)(N(C1)C2=C(F)C3=CC(OC)=CC=C3C=C2O)=O
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Synonyms
PTPN2/1-IN-1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
용액&용해도
DMSO : 100 mg/mL (306.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0647 mL | 15.3233 mL | 30.6466 mL | 76.6166 mL |
| 5 mM | 0.6129 mL | 3.0647 mL | 6.1293 mL | 15.3233 mL | |
| 10 mM | 0.3065 mL | 1.5323 mL | 3.0647 mL | 7.6617 mL | |
| 15 mM | 0.2043 mL | 1.0216 mL | 2.0431 mL | 5.1078 mL | |
| 20 mM | 0.1532 mL | 0.7662 mL | 1.5323 mL | 3.8308 mL | |
| 25 mM | 0.1226 mL | 0.6129 mL | 1.2259 mL | 3.0647 mL | |
| 30 mM | 0.1022 mL | 0.5108 mL | 1.0216 mL | 2.5539 mL | |
| 40 mM | 0.0766 mL | 0.3831 mL | 0.7662 mL | 1.9154 mL | |
| 50 mM | 0.0613 mL | 0.3065 mL | 0.6129 mL | 1.5323 mL | |
| 60 mM | 0.0511 mL | 0.2554 mL | 0.5108 mL | 1.2769 mL | |
| 80 mM | 0.0383 mL | 0.1915 mL | 0.3831 mL | 0.9577 mL | |
| 100 mM | 0.0306 mL | 0.1532 mL | 0.3065 mL | 0.7662 mL |
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