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Cat. No.: HY-159183

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THP-NCS

THP-NCS is a bifunctional chelator bearing an isothiocyanate group, enabling radiolabeling. THP-NCS can conjugate antibody fragments for gallium isotope radiolabeling in ImmunoPET imaging. THP-NCS can conjugate biomolecules, including cyclic RGD peptides. THP-NCS can conjugate PEGylated liposomes or bone-targeting aminobisphosphonates via thiourea bonds for metal chelation pretargeting.

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CAS No.: 1807847-98-8
화학식: C₆₆H₇₄N₁₀O₁₀S₂
분자량:1231.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

THP-NCS Chemical Structure

CAS No.: 1807847-98-8

Amount: USD 0.00

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One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
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References
Calculators
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Classifications
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Biological Activity

제품 설명

IC₅₀ & Target

^[1]

RDC Bifunctional Chelator

All Radionuclide-Drug Conjugates (RDCs) Isoforms :

In Vitro

THP-NCS is linked via a lysine side chain to the cyclic pentapeptide c (RGDfK). The "RGD" peptide motif targets the αvβ3 integrin receptor, which is expressed on the surface of many metastatic tumor cells, as well as on inflammatory tissue and the surface of blood vessels undergoing angiogenesis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS No. 1807847-98-8
분자량 1231.48
화학식 C₆₆H₇₄N₁₀O₁₀S₂
SMILES

O=C1C=C(C)N(C)C(CNC(CCC(CCC(NCC2=C(C(C=C(C)N2C)=O)OCC3=CC=CC=C3)=O)(CCC(NCC4=C(C(C=C(C)N4C)=O)OCC5=CC=CC=C5)=O)NC(CCNC(NC6=CC=C(C=C6)N=C=S)=S)=O)=O)=C1OCC7=CC=CC=C7
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cusnir R, et al. Hydroxypyridinone Chelators: From Iron Scavenging to Radiopharmaceuticals for PET Imaging with Gallium-68. International journal of molecular sciences. 2017 Jan 08;18(1):116.

[2]. Obregon-Perko V, et al. Dynamics and origin of rebound viremia in SHIV-infected infant macaques following interruption of long-term ART. JCI insight. 2021 Dec 08;6(23):e152526.

[3]. Mishra A, et al. Exploring In Vivo Metal Chelation as an Approach for Pretargeted PET Imaging. ACS omega. 2025 May 20;10(19):19379-19393.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
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- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
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THP-NCS

All Radionuclide-Drug Conjugates (RDCs) Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

THP-NCS Related Classifications

HY-159183 Related Classifications

Bioz

Keywords

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