Toddaculin
Based on 1 Customer Validation
Toddaculin is a natural coumarin that can induce differentiation and apoptosis in leukemic cells. Toddaculin suppresses excess osteoclast activity and enhances osteoblast differentiation and mineralization. Toddaculin also exhibits anti-inflammatory activity.
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- Purity: 99.73%
- CAS No.: 4335-12-0
- 화학식: C16H18O4
- 분자량:274.31
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보관:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
Toddaculin (5-250 μM; 24-72 h) shows anti-proliferative activity in U-937 cells, with an IC50 of 51.38 μM[1].
Toddaculin (25-250 μM; 24-48 h) induces partial differentiation in U-937 leukemic cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4335-12-0
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Appearance Solid
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분자량 274.31
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화학식 C16H18O4
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Color White to off-white
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SMILES
O=C1C=CC2=C(OC)C(C/C=C(C)\C)=C(OC)C=C2O1
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
DMSO : 50 mg/mL (182.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Vázquez R, et, al. Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells. Phytomedicine. 2012 Jun 15;19(8-9):737-46. [Content Brief]
[2]. Watanabe A, et, al. Toddaculin, Isolated from of Toddalia asiatica (L.) Lam., Inhibited Osteoclastogenesis in RAW 264 Cells and Enhanced Osteoblastogenesis in MC3T3-E1 Cells. PLoS One. 2015 May 18;10(5):e0127158. [Content Brief]
[3]. Kumagai M, et, al. Evaluation of Aculeatin and Toddaculin Isolated from Toddalia asiatica as Anti-inflammatory Agents in LPS-Stimulated RAW264 Macrophages. Biol Pharm Bull. 2018;41(1):132-137. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6455 mL | 18.2276 mL | 36.4551 mL | 91.1378 mL |
| 5 mM | 0.7291 mL | 3.6455 mL | 7.2910 mL | 18.2276 mL | |
| 10 mM | 0.3646 mL | 1.8228 mL | 3.6455 mL | 9.1138 mL | |
| 15 mM | 0.2430 mL | 1.2152 mL | 2.4303 mL | 6.0759 mL | |
| 20 mM | 0.1823 mL | 0.9114 mL | 1.8228 mL | 4.5569 mL | |
| 25 mM | 0.1458 mL | 0.7291 mL | 1.4582 mL | 3.6455 mL | |
| 30 mM | 0.1215 mL | 0.6076 mL | 1.2152 mL | 3.0379 mL | |
| 40 mM | 0.0911 mL | 0.4557 mL | 0.9114 mL | 2.2784 mL | |
| 50 mM | 0.0729 mL | 0.3646 mL | 0.7291 mL | 1.8228 mL | |
| 60 mM | 0.0608 mL | 0.3038 mL | 0.6076 mL | 1.5190 mL | |
| 80 mM | 0.0456 mL | 0.2278 mL | 0.4557 mL | 1.1392 mL | |
| 100 mM | 0.0365 mL | 0.1823 mL | 0.3646 mL | 0.9114 mL |
Toddaculin Related Classifications
HY-N9359 Related Classifications
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