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Cat. No.: HY-182756

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TREM2 modulator-1

TREM2 modulator-1 is a TREM2 modulator with an EC₅₀ categorized as A and Emax of ++, and can be found in relevant research contexts. TREM2 modulator-1 modulates Triggering Receptor Expressed on Myeloid Cells 2. TREM2 modulator-1 can be used for the research of neurodegenerative diseases.

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CAS No.: 3070235-71-8
화학식: C₂₅H₂₂Cl₂FN₅O₂
분자량:514.38

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

TREM2 modulator-1 Chemical Structure

CAS No.: 3070235-71-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

TREM-2

All TREM receptor Isoforms :

In Vitro

TREM2 modulator-1 (Example 18B) modulates TREM2 in HEK293/DAP12⁺TREM2 cells and activates phosphorylated Syk AlphaScreen signals, with an EC₅₀ of <10 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3070235-71-8
분자량 514.38
화학식 C₂₅H₂₂Cl₂FN₅O₂
SMILES

FC1=C(C=CC(Cl)=C1)C2=NC([C@H]3C[C@@H](C4=CN(C5CC5)N=C4)OCC3)=CN6C2=NC(C)=C(Cl)C6=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Jakob Busch-Petersen, et al. Trem2 modulators. WO2025017059A1. WIPO (PCT). 2024-07-17.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
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TREM2 modulator-1

All TREM receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

TREM2 modulator-1 Related Classifications

HY-182756 Related Classifications