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Trevogrumab

(Synonyms: REGN-1033; SAR391786)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Trevogrumab (REGN-1033) is a monoclonal antibody targeting GDF8 (growth differentiation factor 8, also known as myostatin). Trevogrumab is used in research on muscle wasting conditions, including disuse atrophy, chronic diseases, and changes in food and nutrient intake.

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  • Experimental Validation Results for Trevogrumab
  • Experimental Validation Results for Trevogrumab
  • Experimental Validation Results for Trevogrumab
  • Experimental Validation Results for Trevogrumab
  • Trevogrumab Chemical Structure
    Trevogrumab Chemical Structure
CAS No.: 1429201-24-0
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized GDF-8 Protein, Human/Mouse/Rat (HEK293, HY-P72632) can bind Trevogrumab. The EC50 for this effect is 7.74 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 HeLa cells with Trevogrumab (HY-P99388, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control.

  • 1/16

    Loaded Trevogrumab on ProA biosensor, can bind GDF-8 Protein, Human/Mouse/Rat (HEK293, HY-P72632) with an affinity constant of 2.150E-09 M as determined in BLI assay.

  • Trevogrumab Chemical Structure
    1/16
  • Trevogrumab
  • Immobilized GDF-8 Protein, Human/Mouse/Rat (HEK293, HY-P72632) can bind Trevogrumab. The EC50 for this effect is 7.74 ng/mL.
  • Flow cytometric analysis of 1X106 HeLa cells with Trevogrumab (HY-P99388, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control.
  • Loaded Trevogrumab on ProA biosensor, can bind GDF-8 Protein, Human/Mouse/Rat (HEK293, HY-P72632) with an affinity constant of 2.150E-09 M as determined in BLI assay.