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Cat. No.: HY-113737

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Trichlorfon ethyl

Trichlorfon ethyl is an analog of Trichlorfon (HY-B1220), as well as an inhibitor of Butyrylcholinesterase and Bacillus subtilis Esterase. Trichlorfon ethyl acts as a prenatal brain growth inhibitor, causing mild reductions in total brain weight, medulla oblongata weight and tectum weight in newborn guinea pigs, without affecting cerebellar weight. Trichlorfon ethyl does not induce severe prenatal brain hypoplasia in guinea pig offspring. Trichlorfon ethyl can be used in studies related to brain hypoplasia.

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CAS No.: 993-86-2
화학식: C₆H₁₂Cl₃O₄P
분자량:285.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Trichlorfon ethyl Chemical Structure

CAS No.: 993-86-2

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Biological Activity

제품 설명

IC₅₀ & Target^[2]

BChE

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

Trichlorfon ethyl (Compound Ih) (0.1 mM; 1-10 min) inhibits butyrylcholinesterase from horse blood serum with a k_II of 2.75×10³ L mol^-1 min^-1 and Bacillus subtilis esterase with a k_II of 4.06×10² L mol^-1 min^-1^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Trichlorfon ethyl (121-138 mg/kg; single dose on gestational days 42, 44, 45, 46) produces only minimal, dose-dependent reductions in specific offspring brain region weights in pregnant guinea pigs treated during mid-gestation, with no significant effect on cerebellum weight at tested doses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Outbred albino guinea pigs (Ssc:AL, Mol:DHF; pregnant dams)^[1]
Dosage:

125 mg/kg (gestational days 44, 45, 46); 138 mg/kg (gestational day 42); 121 mg/kg (gestational day 44)
Administration:

Single dose on specified gestational days
Result:

Showed no significant reductions in total brain weight or weights of cerebellum, medulla oblongata, diencephalon, hippocampus, quadrigemina, or cerebral cortex in offspring exposed to 125 mg/kg, compared to saline controls.
Showed a significant reduction in total brain weight (mean 2.47 g, p < 0.05), medulla oblongata weight (mean 163 mg, p < 0.05), and quadrigemina weight (mean 73 mg, p < 0.05), but no significant reduction in cerebellum weight in offspring exposed to 138 mg/kg (day 42) and 121 mg/kg (day 44).
Reduced red blood cell acetylcholinesterase activity to 51% of control levels 24 hours after administration of 125 mg/kg.
Observed no significant changes in glutamate decarboxylase, choline acetyltransferase, or acetylcholinesterase activities in cerebellum, medulla, or cerebral cortex of offspring exposed to ethyl-trichlorfon.

Chemical Information

CAS No. 993-86-2
분자량 285.49
화학식 C₆H₁₂Cl₃O₄P
SMILES

ClC(Cl)(C(O)P(OCC)(OCC)=O)Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Mehl A, et al. The effect of trichlorfon and other organophosphates on prenatal brain development in the guinea pig. Neurochemical research. 1994 May;19(5):569-74. [Content Brief]

[2]. Krutikova V V, et al. Polyfluoroalloxy phosphonic and phosphinic acid derivatives: I. 1-Hydroxy-2, 2, 2-trichloroethylphosphinates[J]. Russian Journal of General Chemistry, 2010, 80(3): 428-433.

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Trichlorfon ethyl

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

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References

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Trichlorfon ethyl Related Classifications

HY-113737 Related Classifications