UCI-1014
Based on 1 Customer Validation
UCI-1014 is a mutant p53 (p53R175H) corrector/reactivator. UCI-1014 restores the wild-type-like DNA-binding activity of p53R175H, promotes the redistribution of the mutant protein to chromatin, and induces the expression of p53-dependent target genes. UCI-1014 inhibits the proliferation of p53R175H-mutant cancer cells through an SLC7A11-independent mechanism. UCI-1014 can be used for research related to p53-mutant cancers.
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- Purity: 98.43%
- CAS No.: 304896-41-1
- 화학식: C16H12N2O4
- 분자량:296.28
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
UCI-1014 (72 h) inhibits the proliferation of TOV-112D cells carrying p53R175H with an IC50 of 4.5 μM[1].
UCI-1014 (10-30 μM; 3 h) restores the DNA-binding ability of p53R175H in TOV-112D cells, and evidence shows that this mutant protein redistributes to the chromatin fraction after treatment with 10 μM or 30 μM for 3 hours[1].
UCI-1014 (3 h) induces p53-dependent gene expression in TOV-112D cells, with a transcriptome profile highly similar to that of UCI-1001, and it induces a greater number of p53-dependent genes after 3 hours of treatment[1].
UCI-1014 (5-20 μM; 72 h) exhibits growth inhibitory activity against TOV-112D cells, and this activity can only be partially reversed by 5 mM N-acetylcysteine (HY-B0215), indicating that its mechanism of action differs from that of thiol-reactive compounds such as APR-246 (HY-19980)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:TOV-112D (p53-R175H)
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Concentration:5 μM, 10 μM, 20 μM
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Incubation Time:72 h
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Result:Had growth-inhibitory effects that were partially alleviated by 5 mM N-acetylcysteine at lower concentrations, but this mitigation diminished at 20 μM.
Chemical Information
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CAS No. 304896-41-1
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Appearance Solid
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분자량 296.28
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화학식 C16H12N2O4
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Color Orange to red
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SMILES
CC1=CC=C(C=C1)C2=CC=C(O2)/C=C3C(NC(NC\3=O)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : 5.83 mg/mL (19.68 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3752 mL | 16.8759 mL | 33.7519 mL | 84.3796 mL |
| 5 mM | 0.6750 mL | 3.3752 mL | 6.7504 mL | 16.8759 mL | |
| 10 mM | 0.3375 mL | 1.6876 mL | 3.3752 mL | 8.4380 mL | |
| 15 mM | 0.2250 mL | 1.1251 mL | 2.2501 mL | 5.6253 mL |
UCI-1014 Related Classifications
HY-183622 Related Classifications
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