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Cat. No.: HY-P99509

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Zelminemab

(Synonyms: AMG-301)

고객리뷰

Based on 1 Customer Validation

Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits PACAP type I (PAC1) receptor.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.79%
CAS No.: 2225850-33-7
분자량:145.22 kDa

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Zelminemab Chemical Structure

CAS No.: 2225850-33-7

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- 신청
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits PACAP type I (PAC1) receptor^[1].

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

In Vivo

Zelminemab (10 mg/kg; i.v.; once) reduces nociceptive neu-ronal activity in the TCC^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats, electricalstimulation was performed on the intact dura mater abovethe middle meningeal artery^[2].
Dosage:

10 mg/kg
Administration:

i.v.; once
Result:

Induced an inhibition of stimulus-evoked nociceptive activity in the trigeminocervical com-plex (TCC).

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

51237 [NCBI]

Accession

Q8WU39

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 kappa

신청

ELISA, FACS, Functional assay

Chemical Information

CAS No. 2225850-33-7
Appearance Liquid
분자량 145.22 kDa
Color Colorless to light yellow
SMILES

[Zelminemab]
Synonyms

AMG-301
선적

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (256 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Eloisa Rubio-Beltrán, et al. PACAP38 and PAC1 receptor blockade: a new target for headache? J Headache Pain. 2018 Aug 7;19(1):64. [Content Brief]

[2]. Hoffmann J, et al. PAC-1 receptor antibody modulates nociceptive trigeminal activity in rat. Cephalalgia. 2016;36(1S):141–141.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- 신청
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Zelminemab

SQ22536

2',5'-Dideoxyadenosine

NKH477

ST034307

LRE1

Peturadol

NKY80

CB-7921220

SQ22536 (Standard)

9-Cyclopentyladenine monomethanesulfonate

2',5'-Dideoxyadenosine (Standard)

NKY80 (Standard)

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

Zelminemab

Cell-ATP Viability Detection Kit

HOLO Human Interleukin-2 (IL-2) Detection Kit

Protein A Agarose

Bradford Protein Assay Kit

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

SQ22536

2',5'-Dideoxyadenosine

NKH477

ST034307

LRE1

Peturadol

NKY80

CB-7921220

SQ22536 (Standard)

9-Cyclopentyladenine monomethanesulfonate

2',5'-Dideoxyadenosine (Standard)

NKY80 (Standard)

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Zelminemab Related Classifications

HY-P99509 Related Classifications

Bioz