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Cat. No.: HY-155556

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ZG36

ZG36 is a human Caseinolytic protease P (ClpP) agonist. ZG36 non-selectively degrades respiratory chain complexes and reduces mitochondrial DNA, ultimately leading to mitochondrial dysfunction and leukemic cell death. ZG36 also inhibits the development of acute myeloid leukemia in a xenograft mouse model.

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CAS No.: 2999673-34-4
화학식: C₃₁H₃₅BrN₄O₄
분자량:607.54

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ZG36 Chemical Structure

CAS No.: 2999673-34-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
HEL	IC₅₀	3.3 μM Compound: ZG36	Antiproliferative activity against human HEL cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human HEL cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37352796]
MOLM-13	IC₅₀	2.9 μM Compound: ZG36	Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37352796]
MV4-11	IC₅₀	5.8 μM Compound: ZG36	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37352796]
NB-4	IC₅₀	4.9 μM Compound: ZG36	Antiproliferative activity against human NB4 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human NB4 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 37352796]

Chemical Information

CAS No. 2999673-34-4
분자량 607.54
화학식 C₃₁H₃₅BrN₄O₄
SMILES

BrC1=CC=C(CNC(N(CC2)[C@]3([H])N([C@H](C(N(C3)CC4=C5C(C=CC=C5)=C(OC)C=C4)=O)[C@H](CC)C)C2=O)=O)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang R, et al. Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists. Eur J Med Chem. 2023 Oct 5;258:115577. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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농도 희석 계산기

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Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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