1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. Lanicemine dihydrochloride

Lanicemine dihydrochloride (Synonyms: AZD6765 dihydrochloride; ARL 15896AR)

Cat. No.: HY-108235A Purity: 99.54% ee.: 99.72%
Handling Instructions

Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects.

For research use only. We do not sell to patients.

Lanicemine dihydrochloride Chemical Structure

Lanicemine dihydrochloride Chemical Structure

CAS No. : 153322-06-6

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10 mM * 1 mL in DMSO Check price and availability
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Description

Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].

IC50 & Target

NMDA receptor[1]

In Vivo

Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1]. Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 3, 10 or 30 mg/kg
Administration: Intraperitoneal
Result: Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity.
Molecular Weight

271.19

Formula

C₁₃H₁₆Cl₂N₂

CAS No.

153322-06-6

SMILES

N[[email protected]](C1=CC=CC=C1)CC2=CC=CC=N2.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 240 mg/mL (884.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6875 mL 18.4373 mL 36.8745 mL
5 mM 0.7375 mL 3.6875 mL 7.3749 mL
10 mM 0.3687 mL 1.8437 mL 3.6875 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 6 mg/mL (22.12 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6 mg/mL (22.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6 mg/mL (22.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

LanicemineAZD6765 ARL 15896ARAZD 6765AZD-6765iGluRIonotropic glutamate receptorsAntidepressantefficacylanicemineNMDAchannelblockerInhibitorinhibitorinhibit

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Product Name:
Lanicemine dihydrochloride
Cat. No.:
HY-108235A
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