1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. Lanicemine

Lanicemine (Synonyms: AZD6765)

Cat. No.: HY-108235 Purity: ≥99.0%
Handling Instructions

Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects.

For research use only. We do not sell to patients.

Lanicemine Chemical Structure

Lanicemine Chemical Structure

CAS No. : 153322-05-5

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Description

Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].

IC50 & Target

NMDA receptor[1]

In Vitro

Cell Line:
Concentration:
Incubation Time:
Result:
In Vivo

Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1]. Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 3, 10 or 30 mg/kg
Administration: Intraperitoneal
Result: Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity.
Molecular Weight

198.26

Formula

C₁₃H₁₄N₂

CAS No.

153322-05-5

SMILES

N[[email protected]](C1=CC=CC=C1)CC2=CC=CC=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: ≥99.0%

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Keywords:

LanicemineAZD6765AZD 6765AZD-6765iGluRIonotropic glutamate receptorsAntidepressantefficacylanicemineNMDAchannelblockerInhibitorinhibitorinhibit

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Lanicemine
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