Lapatinib-d4 tosylate
Lapatinib-d4 (GW572016-d4) tosylate is deuterium labeled Lapatinib (tosylate). Lapatinib (GW572016) tosylate is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2749856-05-9
- Formula: C36H30D4ClFN4O7S2
- Molecular Weight:757.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2749856-05-9
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Unlabeled Cas 1187538-35-7
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Molecular Weight 757.28
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Formula C36H30D4ClFN4O7S2
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SMILES
O=S(O)(C1=CC=C(C=C1)C)=O.CS(C([2H])([2H])C([2H])([2H])NCC2=CC=C(O2)C3=CC(C(NC4=CC(Cl)=C(C=C4)OCC5=CC(F)=CC=C5)=NC=N6)=C6C=C3)(=O)=O
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Synonyms
GW572016-d4 tosylate; GW2016-d4 tosylate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1(2):85-94 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lapatinib-d4 tosylate Related Classifications
HY-50898CS Related Classifications
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