Eicosanoids

11(R)-HPETE is a nucleoside metabolite.

1,2-Di-O-hexadecyl-sn-glycero-3-phosphatidylethanolamine is an ester product.

8(R)-HPETE acts as an intermediate in the conversion of Arachidonic acid to pre-clavulone in Clavularia viridis.

16(R)-HETE, a metabolite of the cytochrome P450 branch of the arachidonate cascade, is a vasodilator.

8(S),15(S)-DiHETE is an ester product.

12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via leukotriene B4 receptor or a common activation sequence.

8(Z),11(Z),14(Z),17(Z)-Octadecatetraenoic acid is a fatty acid.

5,6-DHET is a regioisomer of vic-dihydroxyeicosatrienoic acid and also inhibitor of the hydroosmotic effect of arginine vasopressin.

Leukotriene E3 is a cysteinyl leukotriene metabolite derived from 5,8,11-eicosatrienoic acid (HY-108398A). Leukotriene E3 acts as a smooth-muscle-contracting mediator. Leukotriene E3 can be used for the research of allergic reactions and asthma.

2,3-Dinor-6-keto-prostaglandin F1α (2,3-Dinor-6-keto-PGF1α) is the major urinary metabolite of Prostaglandin I₂ (HY-A0126A). 2,3-Dinor-6-keto-prostaglandin F1α is applicable to the research of coronary heart disease.

13,14-dihydro-19(R)-hydroxy Prostaglandin E1 is the theoretical metabolite of 13,14-dihydro PGE1 by ω-1 hydroxylase.

5-trans-17-phenyl trinor Prostaglandin F2α (5-trans-17-phenyl trinor PGF2α) is the 5-trans isomer of HY-B0191 Bimatoprost (17-phenyl trinor PGF2α).

17-phenyl trinor Prostaglandin F2α isopropyl amide is a derivative of 17-phenyl trinor prostaglandin F2α ethyl amide.17-Phenyl trinor prostaglandin E2 ethyl amide (17-Phenyl trinor PGE2 ethyl amide) is a EP1 receptor agonist. 17-Phenyl trinor prostaglandin E2 ethyl amide aggravates renal dysfunction and glomerulosclerosis.

Prostaglandin A2-biotin (PGA2-biotin) is a biotin-labeled Prostaglandin A2 (HY-113041). Prostaglandin A2-biotin retains the activity of inhibiting cellular proliferation. Prostaglandin A2-biotin is an effective tool for studying the interaction between Prostaglandin A2 and cellular proteins and exploring the mechanism of its inhibition of cellular proliferation.

8(9)-EET is one of the main metabolites produced by the metabolism of arachidonic acid (HY-109590) through the cytochrome P450 epoxide pathway. 8(9)-EET is an effective substrate for COX-1 and COX-2. 8(9)-EET activates PPARα in HEK293 cells and inhibits the activity of NF-κB induced by IL-1β in a PPARα-dependent and -independent manner. The (8S,9R)-isomer of 8(9)-EET ([(8S,9R)-EET]) causes vasoconstriction, thereby reducing renal plasma flow and glomerular filtration rate.

2,3-Dinor-8-iso prostaglandin F₂α (2,3-Dinor-8-isoPGF2α) is the major β-oxidation metabolite of 8-iso-prostaglandin F₂α. 2,3-Dinor-8-iso prostaglandin F₂α serves as a biomarker to evaluate the in vivo production of 8-iso-prostaglandin F₂α and the level of lipid peroxidation. 2,3-Dinor-8-iso prostaglandin F₂α is promising for research of oxidative stress-related diseases such as arteriosclerosis and diabetes.

15-keto Prostaglandin F1α (15-keto PGF1α) is a prostaglandin F1α metabolite. 15-keto Prostaglandin F1α (15-keto PGF1α) is an effective substrate for PGR-2. 15-keto Prostaglandin F1α (15-keto PGF1α) can be used to study physiological processes such as prostaglandin metabolism and lipogenesis.

11-Deoxy prostaglandin F1β is a synthetic analog of PGF1β. 11-Deoxy prostaglandin F1β exhibits vasodepressor and bronchodilator activities in guinea pigs.

6,15-Diketo-13,14-dihydro prostaglandin F1α (6,15-Diketo-13,14-dihydro-PGF1α) is a metabolite of prostacyclin (PGI2). 6,15-Diketo-13,14-dihydro prostaglandin F1α enhances intracellular cAMP and cholesterol metabolism in bovine arterial smooth muscle cells.

8-iso-13,14-dihydro-15-keto Prostaglandin F2α is an oxidative metabolite of 8-iso-prostaglandin F_2α (HY-113209). 8-iso-13,14-dihydro-15-keto Prostaglandin F2α can be used in the study of oxidative stress-related diseases.