Eicosanoids

11,12-DiHETrE is a dihydroxy fatty acid metabolite of Arachidonic Acid (HY-109590). 11,12-DiHETrE is converted to 11,12-DiHETrE under elevated soluble epoxide hydrolase (sEH) activity, a process closely related to inflammation and oxidative stress. 11,12-DiHETrE can serve as a single biomarker to differentiate between NAFL (non-alcoholic fatty liver disease) and NASH (non-alcoholic steatohepatitis). 11,12-DiHETrE can be used in studies on preterm birth, autism, and pulmonary hypertension.

5-trans Prostaglandin F2α is an endogenous metabolite present in Blood that can be used for the research of Myocardial Infarction.

20-Hydroxy-leukotriene B4 is an endogenous metabolite present in Urine that can be used for the research of Sjogren Larsson Syndrome.

Bimatoprost methyl ester is a proagent of Bimatoprost (HY-B0191).

N-Desethyl Bimatoprost is a N-desethyl metabolite of Bimatoprost (HY-B0191).

6-trans-12-epi-Leukotriene B4, an arachidonic acid metabolite, is a potent anti-inflammatory agent.

6-trans-leukotriene B4 is a neutrophil chemotaxin in the guinea pig dermis.

11-trans Leukotriene E4 is an isomer of Leukotriene E4 (LTE4). Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans Leukotriene E4 is equipotent to LTE4 in contracting guinea pig ileum.

Tetranor-PGDM is an abundant urinary metabolite reflects biosynthesis of prostaglandin D₂.

Leukotriene F4 (LTF4), is a lipid that belongs to the Cysteinyl Leukotriene (CysTL) family. Leukotriene F4 induces bronchoconstriction with an ED₅₀ of 16 μg/kg. The precursor of LTF4 is Leukotriene E4 (LTE4), which isformed from the action of a glutamyl transferase.

Unoprostone, a prostaglandin F2α analog, is a large conductance Ca²⁺-activated K⁺ (BK) channels and ClC-2 type chloride channels activator. Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction. Unoprostone reduces intraocular pressure and can be used for the study of glaucoma, ocular hypertension and retinitis pigmentosa.

Leukotriene E3 is a cysteinyl leukotriene metabolite derived from 5,8,11-eicosatrienoic acid (HY-108398A). Leukotriene E3 acts as a smooth-muscle-contracting mediator. Leukotriene E3 can be used for the research of allergic reactions and asthma.

11-Dehydro thromboxane B3 (11-Dehydro-TXB3) is a pro-inflammatory thromboxane lipid mediator that the body generates following administration of eicosapentaenoic acid. 11-Dehydro thromboxane B3 is an enzymatic metabolite of Thromboxane B3 (HY-113445) and also serves as a biomarker for Thromboxane A3 biosynthesis in humans in vivo. 11-Dehydro thromboxane B3 is used in metabolism-related research.

8-isoprostaglandin F2α ethanolamide (iPF2α-III ethanolamide; 8-Isoprostane ethanolamide; 8-iso PGF2α ethanolamide) is an isoprostanol ethanolamide derivative derived from anandamide (AEA) via non-enzymatic free radical oxidation. 8-isoprostaglandin F2α ethanolamide is commonly used as a marker of oxidative stress, distinguishing non-enzymatic degradation products from "prostamides" generated by enzymatic pathways such as COX-2.

(±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC₅₀ values of 24 and 25 μM, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC₅₀s=8.6-8.8 μM).

13,14-Dihydro-15-keto-tetranor prostaglandin E2 (13,14-Dihydro-15-keto-tetranor PGE2) is a potential metabolite of Prostaglandin E2 (HY-101952).

5R(6S)-EET is the metabolite of Arachidonic acid (HY-109590). 5R(6S)-EET activates the synthesis of endogenous prostaglandin (PGE2), which inhibits the Na⁺ absorption, increases the intracellular Ca²⁺, and promotes the depolarization of transmembrane voltage. 5R(6S)-EET exhibits stereoselectivity with less effectness than 5S(6R)-EET (HY-168382A).

15(R)-Hydroxy-11(Z),13(E)-eicosadienoic acid is an ester product.