Hydroxy Fatty Acids

Leukotriene F4 (LTF4), is a lipid that belongs to the Cysteinyl Leukotriene (CysTL) family. Leukotriene F4 induces bronchoconstriction with an ED₅₀ of 16 μg/kg. The precursor of LTF4 is Leukotriene E4 (LTE4), which isformed from the action of a glutamyl transferase.

Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA), the R enantiomer of (Rac)-Idroxioleic acid, is an orally active fatty acid that modulates the lipid composition and structure of the membranes. Idroxioleic acid has antitumor activities.

FR901465 is a potent anti-cancer and anti-tumor agent. FR901465 can be used for cancer research.

Hydroxyl-γ-isosanshool is one of the major alkylamides in Z. bungeanum and Z. schinifolium oils. Hydroxyl-γ-isosanshoo induces a numbing sensation.

Hydroxy-Epsilon-Sanshool is an alkylamide isolated from Zanthoxylum bungeanum. Hydroxy-Epsilon-Sanshool produces key tingling and numbing chemosensates, and its content is important in determinant the pungency intensity of Zanthoxylum bungeanum.

Leukotriene E3 is a cysteinyl leukotriene metabolite derived from 5,8,11-eicosatrienoic acid (HY-108398A). Leukotriene E3 acts as a smooth-muscle-contracting mediator. Leukotriene E3 can be used for the research of allergic reactions and asthma.

Isovaleryl-CoA sodium is a branched-chain acyl-CoA and an inhibitor of succinate-CoA ligase (SCL), with an IC₅₀ of 273 μM in rat liver mitochondria.

11-Dehydro thromboxane B3 (11-Dehydro-TXB3) is a pro-inflammatory thromboxane lipid mediator that the body generates following administration of eicosapentaenoic acid. 11-Dehydro thromboxane B3 is an enzymatic metabolite of Thromboxane B3 (HY-113445) and also serves as a biomarker for Thromboxane A3 biosynthesis in humans in vivo. 11-Dehydro thromboxane B3 is used in metabolism-related research.

12-Hydroxy-9(E)-octadecenoic acid ((E)-12-Hydroxyoctadec-9-enoic acid) is an ester product.

3-Hydroxy-4(E)-nonenoic acid is an ester product.

(Z)-3-Hydroxynon-6-enoic acid (3-Hydroxy-6(Z)-nonenoic acid) is an ester product.

19-Hydroxynonadecanoic acid is a PROTAC linker that can be used in the synthesis of PROTACs.

7,17-Dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid ((2E,7S,8Z,10Z,13Z,15E,17S)-7,17-Dihydroxydocosa-2,8,10,13,15-pentaenoic acid) is an ester product.

Mycolic acid IIa is a structural lipid component of mycobacterial cell wall. Mycolic acid IIa can be isolated from Mycobacterium bovis BCG. Mycolic acid IIa significantly modulates membrane permeability and stability, promising for mycobacterium tuberculosis infection research.

9(S),10(S),13(S)-Trihydroxy-11(E),15(Z)-octadecadienoic acid is an ester product.

(±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC₅₀ values of 24 and 25 μM, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC₅₀s=8.6-8.8 μM).

13,14-Dihydro-15-keto-tetranor prostaglandin E2 (13,14-Dihydro-15-keto-tetranor PGE2) is a potential metabolite of Prostaglandin E2 (HY-101952).