Sphingolipids

C12 Sphingosyl PE (d17:1/12:0) is a phosphosphingolipid.

C25 Ceramide (d18:1/25:0) is an endogenous ultra-long-chain ceramide that antagonizes the detrimental effects of long-chain ceramides on insulin sensitivity. C25 Ceramide (d18:1/25:0) is specifically enriched in oxidative skeletal muscle fibers, where it serves dual roles in providing structural support to cell membranes and regulating cellular signaling. By participating in the regulation of lipid homeostasis within muscle fibers, C25 Ceramide (d18:1/25:0) helps maintain normal insulin signaling. C25 Ceramide (d18:1/25:0) is primarily utilized in research concerning metabolic diseases—particularly in mechanistic studies investigating the muscle fiber type-specific aspects of insulin resistance.

Globotriaosylceramide porcine RBC (Ceramide trihexosides porcine) is a neutral glycosphingolipid belonging to the globoside series of erythrocytes, primarily isolated and extracted from porcine RBC. Globotriaosylceramide porcine RBC is a natural resistance factor against HIV-1 infection. Globotriaosylceramide porcine RBC blocks viral binding to CXCR4/CCR5 co-receptors through competitive binding to the V3 loop region of HIV-1 gp120, thereby inhibiting viral fusion and entry. Globotriaosylceramide porcine RBC is the major cell surface receptor for Shiga toxin. Globotriaosylceramide porcine RBC can be used for research on hemolytic uremic syndrome, HIV-1 infection, and Fabry disease.

C24:1 Mono-sulfo Galactosyl (β) ceramide (d18:1/24:1) (ammonium) is a glycosphingolipid.

C18:0 GM1 Ganglioside-d₅ (ammonium) is deuterium labeled C18:0 GM1 Ganglioside (ammonium).

C16 Ceramide (Cer) (d18:1(14Z)/16:0) is a sphingosine ceramide composed of long-chain sphingosine (d18:1) and palmitic acid (C16:0). It is one of the key lipid signaling molecules involved in apoptosis signaling. C16 ceramides are particularly involved in cell cycle arrest, cell death, and insulin signaling inhibition.

EOP (t18:0/30:0/18:2) (C48:2 EOP (t18:0/30:0w18:2 (9Z,12Z)); N-(30-Linoleoyloxy-triacontanoyl)-phytosphingosine) is a plant ceramide-based EOS analog. EOP (t18:0/30:0/18:2) is formed by esterifying an ω-hydroxy very long chain ceramide (C28-36) with the essential fatty acid linoleic acid. EOP (t18:0/30:0/18:2) has been used as a component of a model stratum corneum lipid mixture.

N-Glycine lactosylsphingosine (d18:1) is a glycinated lactosylsphingosine.

(2S)-3-Keto sphinganine (d6:0) ((2S)-3-Keto-C6-dihydrosphingosine) hydrochloride is a lipid compound that can be used for liposome preparation. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble loads can be captured in the internal aqueous space of liposomes, while lipophilic loads can be distributed into the lipid bilayer and become part of the lipid bilayer. Especially for the delivery of antisense oligonucleotides, it can overcome the problems of inefficient cellular uptake and rapid loss in the body.

N-Glycine galactosylsphingosine (d18:1) (N-Glycine psychosine) is a glycinated form of galactosylsphingosine (HY-136490).

C18:1 Galactosyl(β) ceramide (d18:1/18:1(9Z)) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

N-Tricosanoyl ceramide trihexoside (C23 Globotriaosylceramide (d18:1/23:0)) is an ester product.

C6 Ceramide (d18:1/6:0) alkyne is an ω-alkyne derivative of C6 ceramide. The terminal alkyne group can be used in click chemistry reactions to tag C6 ceramide with fluorescent or biotinylated labels, allowing the analysis of the metabolism and biological activity of C6 ceramide.

C24:1 Mono-sulfo Galactosyl (α) ceramide (d18:1/24:1) (ammonium) is a glycosphingolipid.

C8 L-threo ceramide (d18:1/8:0) (N-Octanoyl-L-threo-sphingosine) is an ester product.

C11-BODIPY 505/515 Galactosyl ceramide is a C11-BODIPY 505/515-labeled Galactosyl ceramide that can be used to prepare lipid nanoparticles for drug delivery (Ex/Em = 505/515 nm).

C18(2S-OH) Galactosyl(β) ceramide is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

α-Galactosyl-C16-dihydroceramide (d18:0/16:0) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

C24:0 Galactosyl(β)ceramide(d18:1/24:0) is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

Lactosylceramide (LacCer) (porcine RBC) is an endogenous bioactive sphingolipid. Lactosylceramide (porcine RBC) plays a pivotal role in mediating innate immune functions.