1. GPCR/G Protein
  2. Oxytocin Receptor
  3. LIT-001

LIT-001 

Cat. No.: HY-124733A Purity: 98.52%
Handling Instructions

LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). LIT-001 improves social interaction in a mouse model of autism.

For research use only. We do not sell to patients.

LIT-001 Chemical Structure

LIT-001 Chemical Structure

CAS No. : 2245072-21-1

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 271 In-stock
Estimated Time of Arrival: December 31
5 mg USD 190 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
25 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). LIT-001 improves social interaction in a mouse model of autism[1].

IC50 & Target

EC50: 55 nM (OT-R)[1]
Ki: 226 nM (OT-R)[1]

In Vitro

In vitro signaling experiments, LIT-001 is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only[1].

In Vivo

LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD )[1].

Animal Model: Oprm1–/– mice (bred in house on a 50% 129SVPas–50% C57BL/6J hybrid background)[1]
Dosage: 10, 20 mg/kg
Administration: i.p.
Result: Alleviated core symptoms in the context of ASD.
Molecular Weight

645.70

Formula

C₃₀H₃₄F₃N₇O₄S

CAS No.

2245072-21-1

SMILES

O=C(N1[[email protected]](C(N(C)C)=S)CCC1)NCC2=CC=C(C(N3C4=CC=CC=C4NC(N(C)N=C5)=C5C3)=O)C=C2C.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (387.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5487 mL 7.7435 mL 15.4871 mL
5 mM 0.3097 mL 1.5487 mL 3.0974 mL
10 mM 0.1549 mL 0.7744 mL 1.5487 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (3.36 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (3.36 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (3.36 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

LIT-001LIT001LIT 001Oxytocin ReceptorOXTRnonpeptidesocialinteractionV1aV2vasopressinreceptorautismspectrumdisordersnonbiasedInhibitorinhibitorinhibit

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LIT-001
Cat. No.:
HY-124733A
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