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Cat. No.: HY-160183

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LSD1-IN-29

LSD1-IN-29 (compound 6) is a Lysine specific demethylase 1 (LSD1) inhibitor with the IC₅₀ of 19 nM.

For research use only. We do not sell to patients.

CAS No.: 1496573-83-1
Formula: C₁₉H₂₁N₃O₅S
Molecular Weight:403.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

LSD1-IN-29 Chemical Structure

CAS No.: 1496573-83-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
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Bioz

Biological Activity

Description

LSD1-IN-29 (compound 6) is a Lysine specific demethylase 1 (LSD1) inhibitor with the IC₅₀ of 19 nM^[1].

All Histone Demethylase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
EC9706	IC₅₀	1.22 μM Compound: 6d	Antiproliferative activity against human EC9706 cells after 72 hrs by MTT assay Antiproliferative activity against human EC9706 cells after 72 hrs by MTT assay	[PMID: 29475156]
ECa-109 cell line	IC₅₀	5.45 μM Compound: 6d	Antiproliferative activity against human EC109 cells after 72 hrs by MTT assay Antiproliferative activity against human EC109 cells after 72 hrs by MTT assay	[PMID: 29475156]
MCF7	IC₅₀	5.4 μM Compound: 6d	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 29475156]
MGC-803	IC₅₀	1.22 μM Compound: 6d	Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay	[PMID: 29475156]
PC-3	IC₅₀	2.81 μM Compound: 6d	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	[PMID: 29475156]
SMMC-7721	IC₅₀	1.37 μM Compound: 6d	Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay	[PMID: 29475156]
T47D	IC₅₀	0.524 μM Compound: 6	Growth inhibition of human T47D cells after 96 hrs by ATPlite luminescence assay Growth inhibition of human T47D cells after 96 hrs by ATPlite luminescence assay	[PMID: 24237195]

Chemical Information

CAS No. 1496573-83-1
Molecular Weight 403.45
Formula C₁₉H₂₁N₃O₅S
SMILES

O=S(C1=CC(C(N/N=C(C2=C(C=CC=C2)O)\C)=O)=CC=C1)(N3CCOCC3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sorna V, et al. High-throughput virtual screening identifies novel N'-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors. J Med Chem. 2013;56(23):9496-9508. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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References

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LSD1-IN-29

All Histone Demethylase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

LSD1-IN-29 Related Classifications

HY-160183 Related Classifications