2. Epigenetics
  3. Histone Demethylase
  4. LSD1-IN-29

LSD1-IN-29 (compound 6) is a Lysine specific demethylase 1 (LSD1) inhibitor with the IC50 of 19 nM.

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LSD1-IN-29

LSD1-IN-29 Chemical Structure

CAS No. : 1496573-83-1

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LSD1-IN-29 Related Antibodies

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KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

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Description

LSD1-IN-29 (compound 6) is a Lysine specific demethylase 1 (LSD1) inhibitor with the IC50 of 19 nM[1].

Cellular Effect
Cell Line Type Value Description References
EC9706 IC50
1.22 μM
Compound: 6d
Antiproliferative activity against human EC9706 cells after 72 hrs by MTT assay
Antiproliferative activity against human EC9706 cells after 72 hrs by MTT assay
[PMID: 29475156]
MCF7 IC50
5.4 μM
Compound: 6d
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 29475156]
MGC-803 IC50
1.22 μM
Compound: 6d
Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay
Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay
[PMID: 29475156]
PC-3 IC50
2.81 μM
Compound: 6d
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
[PMID: 29475156]
SMMC-7721 IC50
1.37 μM
Compound: 6d
Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay
Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay
[PMID: 29475156]
T47D IC50
0.524 μM
Compound: 6
Growth inhibition of human T47D cells after 96 hrs by ATPlite luminescence assay
Growth inhibition of human T47D cells after 96 hrs by ATPlite luminescence assay
[PMID: 24237195]
Molecular Weight

403.45

Formula

C19H21N3O5S
CAS No.
SMILES

O=S(C1=CC(C(N/N=C(C2=C(C=CC=C2)O)\C)=O)=CC=C1)(N3CCOCC3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LSD1-IN-29 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1-IN-291496573-83-1Histone DemethylaseBreast cancerrectal cancerLysine specific demethylase 1Inhibitorinhibitorinhibit

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