2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-B-IN-55

MAO-B-IN-55 (Compound 5c) is a reversible competitive MAO-B inhibitor with an IC50 of 2.9 nM, and it exhibits approximately 2750-fold higher selectivity for MAO-B over MAO-A. MAO-B-IN-55 can be used for the research of Parkinson's disease.

For research use only. We do not sell to patients.

MAO-B-IN-55

MAO-B-IN-55 Chemical Structure

CAS No. : 1458219-02-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
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MAO-B-IN-55 Related Antibodies

Top Publications Citing Use of Products

View All Monoamine Oxidase Isoform Specific Products:

View All Isoforms
MAO-A MAO-B

  • Biological Activity

  • Purity & Documentation

  • References

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Description

MAO-B-IN-55 (Compound 5c) is a reversible competitive MAO-B inhibitor with an IC50 of 2.9 nM, and it exhibits approximately 2750-fold higher selectivity for MAO-B over MAO-A. MAO-B-IN-55 can be used for the research of Parkinson's disease[1].

IC50 & Target[1]

MAO-B

2.9 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
PC-12 Survival
108.19 %
Compound: 28
Cytotoxicity against rat PC12 cells assessed as cell survival at 20 uM after 72 hrs by MTT assay relative to control
Cytotoxicity against rat PC12 cells assessed as cell survival at 20 uM after 72 hrs by MTT assay relative to control
[PMID: 27692996]
PC-12 Survival
111.71 %
Compound: 28
Neuroprotective activity against 6-OHDA-induced toxicity in rat PC12 cells assessed as cell survival at 20 uM preincubated for 24 hrs followed by 6-OHDA addition measured after 24 hrs by MTT assay relative to control
Neuroprotective activity against 6-OHDA-induced toxicity in rat PC12 cells assessed as cell survival at 20 uM preincubated for 24 hrs followed by 6-OHDA addition measured after 24 hrs by MTT assay relative to control
[PMID: 27692996]
PC-12 Survival
133.52 %
Compound: 28
Neuroprotective activity against rotenone-induced toxicity in rat PC12 cells assessed as cell survival at 20 uM preincubated for 24 hrs followed by rotenone addition measured after 24 hrs by MTT assay relative to control
Neuroprotective activity against rotenone-induced toxicity in rat PC12 cells assessed as cell survival at 20 uM preincubated for 24 hrs followed by rotenone addition measured after 24 hrs by MTT assay relative to control
[PMID: 27692996]
PC-12 Survival
80.24 %
Compound: 28
Cytotoxicity against rat PC12 cells assessed as cell survival at 100 uM after 24 hrs by MTT assay relative to control
Cytotoxicity against rat PC12 cells assessed as cell survival at 100 uM after 24 hrs by MTT assay relative to control
[PMID: 27692996]
Molecular Weight

332.20

Formula

C16H14BrNO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2=CC(OCC=3C=CC=C(Br)C3)=CC=C2CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (376.28 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0102 mL 15.0512 mL 30.1023 mL
5 mM 0.6020 mL 3.0102 mL 6.0205 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0102 mL 15.0512 mL 30.1023 mL 75.2559 mL
5 mM 0.6020 mL 3.0102 mL 6.0205 mL 15.0512 mL
10 mM 0.3010 mL 1.5051 mL 3.0102 mL 7.5256 mL
15 mM 0.2007 mL 1.0034 mL 2.0068 mL 5.0171 mL
20 mM 0.1505 mL 0.7526 mL 1.5051 mL 3.7628 mL
25 mM 0.1204 mL 0.6020 mL 1.2041 mL 3.0102 mL
30 mM 0.1003 mL 0.5017 mL 1.0034 mL 2.5085 mL
40 mM 0.0753 mL 0.3763 mL 0.7526 mL 1.8814 mL
50 mM 0.0602 mL 0.3010 mL 0.6020 mL 1.5051 mL
60 mM 0.0502 mL 0.2509 mL 0.5017 mL 1.2543 mL
80 mM 0.0376 mL 0.1881 mL 0.3763 mL 0.9407 mL
100 mM 0.0301 mL 0.1505 mL 0.3010 mL 0.7526 mL
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MAO-B-IN-55 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-551458219-02-7Monoamine OxidaseMAOMAO-Arecombinant human MAO-Arecombinant human MAO-BMAO-Bparkinson’s diseaseInhibitorinhibitorinhibit

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