MAO-B-IN-63
MAO-B-IN-63 (compound 4d) is a selective human monoamine oxidase-B (MAO-B) inhibitor with an IC50 of 0.581 μM. MAO-B-IN-63 blocks the catalytic cycle of monoamine oxidase, thereby reducing neurotransmitter metabolism and hydrogen peroxide production. MAO-B-IN-63 can be used in the research of Parkinson's disease.
For research use only. We do not sell to patients.
- CAS No.: 1898180-91-0
- Formula: C18H14N2O3
- Molecular Weight:306.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MAO-B-IN-63 (Compound 4d) (3 nM-100 μM) inhibits recombinant human MAO-B with an IC50 of 0.581 μM; it inhibits MAO-A with an IC50 of 1.75 μM, and acts as a MAO-B-preferring inhibitor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1898180-91-0
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Molecular Weight 306.32
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Formula C18H14N2O3
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SMILES
O=C(NC1=O)C2=C1C=C(N(OC)C(C3=CC=C(C)C=C3)=C4)C4=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAO-B-IN-63 Related Classifications
HY-186308 Related Classifications
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