2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Metribuzin

Metribuzin is a low-cost non-selective herbicide belonging to the chemical class of triazinones. Metribuzin inhibits plant DNA synthesis and acts on photosystem II, ultimately suppressing photosynthesis. Metribuzin provides excellent control of important annual grass and broadleaf weeds.

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Metribuzin

Metribuzin Chemical Structure

CAS No. : 21087-64-9

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Metribuzin Related Antibodies

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Description

Metribuzin is a low-cost non-selective herbicide belonging to the chemical class of triazinones. Metribuzin inhibits plant DNA synthesis and acts on photosystem II, ultimately suppressing photosynthesis. Metribuzin provides excellent control of important annual grass and broadleaf weeds[1][2].

In Vitro

Metribuzin inhibits photosystem II electron transport in plant chloroplasts, exerting herbicidal effects[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Metribuzin Related Antibodies
In Vivo

Metribuzin (105-175 g a.i ha-1 + Ad-500 400 mL ha-1; 105-175 g a.i ha-1 + Bio-power 400 mL ha-1; foliar spray; single application at two- to four-leaf weed stage) 175 g a.i ha-1 + Bio-power 400 mL ha-1 provides the most effective control of associated wheat weeds and maximizes wheat grain yield (3.91 kg ha-1), while metribuzin combinations with adjuvants improve efficacy over metribuzin alone at all tested doses[1].
Metribuzin (6.44 mg/kg) disrupts glomerular function in pregnant rabbits[2].
Metribuzin (single dose; p.o.) has an acute oral LD50 of 1090 mg/kg in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[2]
Dosage: single dose (LD50 determination)
Administration: p.o.
Result: Reached an oral LD50 of 1090 mg/kg.
Molecular Weight

214.29

Formula

C8H14N4OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C(SC)=NN=C1C(C)(C)C)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 87.5 mg/mL (408.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6666 mL 23.3329 mL 46.6657 mL
5 mM 0.9333 mL 4.6666 mL 9.3331 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6666 mL 23.3329 mL 46.6657 mL 116.6643 mL
5 mM 0.9333 mL 4.6666 mL 9.3331 mL 23.3329 mL
10 mM 0.4667 mL 2.3333 mL 4.6666 mL 11.6664 mL
15 mM 0.3111 mL 1.5555 mL 3.1110 mL 7.7776 mL
20 mM 0.2333 mL 1.1666 mL 2.3333 mL 5.8332 mL
25 mM 0.1867 mL 0.9333 mL 1.8666 mL 4.6666 mL
30 mM 0.1556 mL 0.7778 mL 1.5555 mL 3.8888 mL
40 mM 0.1167 mL 0.5833 mL 1.1666 mL 2.9166 mL
50 mM 0.0933 mL 0.4667 mL 0.9333 mL 2.3333 mL
60 mM 0.0778 mL 0.3889 mL 0.7778 mL 1.9444 mL
80 mM 0.0583 mL 0.2917 mL 0.5833 mL 1.4583 mL
100 mM 0.0467 mL 0.2333 mL 0.4667 mL 1.1666 mL
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Metribuzin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metribuzin21087-64-9DNA/RNA Synthesiswheatannual grass weedsphotosystem IIratstomatoespregnant rabbitsD1 proteinbroadleaf weedsQB sitepotatoesInhibitorinhibitorinhibit

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