2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. MEY-003

MEY-003 is an Autotaxin(ATX) inhibitor with EC50s of 460 nM and 1.09 μM for hATX-β and hATX-ɣ (analysis with LPC18:1). MEY-003 behaves as a non-competitive inhibitor with K iof 432 nM. MEY-003 can be used for targeted ATX-related disease research .

For research use only. We do not sell to patients.

MEY-003 Chemical Structure

MEY-003 Chemical Structure

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MEY-003 Related Antibodies

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Description

MEY-003 is an Autotaxin(ATX) inhibitor with EC50s of 460 nM and 1.09 μM for hATX-β and hATX-ɣ (analysis with LPC18:1). MEY-003 behaves as a non-competitive inhibitor with K iof 432 nM. MEY-003 can be used for targeted ATX-related disease research [1].

IC50 & Target

Autotaxin

 

In Vitro

MEY-003 (10 μM, 30 min) blocks lysophosphatidic acid (LPA) signaling, and reduces LPA1 receptor internalization in HeLa cell[1].
MEY-003 (100 μM, 0-24 h) shows no cytotoxicity effects in HeLa and HEK293 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MEY-003 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HeLa and HEK293 cells
Concentration: 100 μM
Incubation Time: 0-24 h
Result: Showed non-cytotoxic after prolonged treatment (up to 24 h) at 100 μM with HeLa cells or HEK293 cells.
Molecular Weight

365.42

Formula

C22H23NO4
SMILES

OC1=C2C(OC(C3C(C=CC=C4)=C4N(CCCCC)C3)=CC2=O)=CC(O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MEY-003 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MEY-003MEY003MEY 003Phosphodiesterase (PDE)HeLaHEK293 cellsInhibitorATXinhibitorinhibit

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