MJBIA9836
Based on 1 Customer Validation
MJBIA9836 is a MAGE-A3 ligand with a Kd of approximately 8.1 μM. MJBIA9836 elevates MAGE-A3 levels in MAGE-A3-positive cells. MJBIA9836 serves as a Ligand for Target Protein for PROTAC for the synthesis of MAGE-A3 PROTAC degraders, such as KL-465 (HY-169086). MJBIA9836 can be used in the research of MAGE-A3-positive cancers.
For research use only. We do not sell to patients.
- Purity: 99.67%
- CAS No.: 3057446-77-9
- Formula: C24H24N4O3
- Molecular Weight:416.47
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MJBIA9836 binds to purified MAGE-A3 MHD protein with a low-micromolar affinity (KD = 8.3 μM) in a 1:2 ligand-to-protein stoichiometry[1].
MJBIA9836 (43 μM) does not disrupt the interaction between purified MAGE-A3 MHD and TRIM28 RBCC protein, as indicated by minimal reduction in TR-FRET signal at 43 μM[1].
MJBIA9836 (10 μM; 72 h) causes minimal reduction in viability of MAGE-A3-positive cancer cell lines and no significant toxicity in MAGE-A3-negative cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MAGE-A3-positive cell lines (HCT116 p53(-), HCT116 p53(+), A375, HeLa), MAGE-A3-negative cell lines (HEK293, MOLM13)
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Concentration:10 μM
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Incubation Time:72 h
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Result:Reduced cell viability to a lesser extent than the MAGE-A3 degrader KL465 in MAGE-A3-positive cell lines, with viability remaining above 70% in most lines (HCT116 p53(-): ~120%, HCT116 p53(+): ~110%, A375: ~90%, HeLa: ~90%).
Did not significantly reduce cell viability in MAGE-A3-negative cell lines (HEK293: ~125%, MOLM13: ~80%).
Chemical Information
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CAS No. 3057446-77-9
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Appearance Solid
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Molecular Weight 416.47
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Formula C24H24N4O3
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Color White to off-white
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SMILES
O=C(C1=CC=CO1)N2CCN(CC3=CC(C4=CC=CC5=C4C=NN5)=CC=C3OC)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (275 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MJBIA9836 Related Classifications
HY-169087 Related Classifications
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