1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. MLS000544460

MLS000544460 

Cat. No.: HY-133511 Purity: 99.74%
Handling Instructions

MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a Kd of 2.0 μM and an IC50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity.

For research use only. We do not sell to patients.

MLS000544460 Chemical Structure

MLS000544460 Chemical Structure

CAS No. : 352336-36-8

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5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
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25 mg USD 850 In-stock
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50 mg USD 1350 In-stock
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100 mg USD 1950 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a Kd of 2.0 μM and an IC50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity[1].

IC50 & Target

Kd: 2.0 μM (Eya2 phosphatase)[1]
IC50: 4 μM (Eya2 phosphatase)[1]

In Vitro

MLS000544460 does not bind Eya3 phosphatase (ED)[1].
MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells[1].
When Eya2 ED is dialyzed into 10 μM EDTA to remove Mg2+, it binds MLS000544460 with a higher affinity (Kd=0.80 μM), indicating that this class of compounds does not require Mg2+ for its interaction with the Eya2 ED[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

341.36

Formula

C₁₇H₁₂FN₃O₂S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (366.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9295 mL 14.6473 mL 29.2946 mL
5 mM 0.5859 mL 2.9295 mL 5.8589 mL
10 mM 0.2929 mL 1.4647 mL 2.9295 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.09 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
MLS000544460
Cat. No.:
HY-133511
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