1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. MLS000544460

MLS000544460 

Cat. No.: HY-133511
Handling Instructions

MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a Kd of 2.0 μM and an IC50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity.

For research use only. We do not sell to patients.

MLS000544460 Chemical Structure

MLS000544460 Chemical Structure

CAS No. : 352336-36-8

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Description

MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a Kd of 2.0 μM and an IC50 of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity[1].

IC50 & Target

Kd: 2.0 μM (Eya2 phosphatase)[1]
IC50: 4 μM (Eya2 phosphatase)[1]

In Vitro

MLS000544460 does not bind Eya3 phosphatase (ED)[1].
MLS000544460 (10 μM) inhibits Eya2-mediated cell migration in human Eya2, Eya2 phosphatase-dead (D274N), and YFP (as a negative control) expressing MCF10A cells[1].
When Eya2 ED is dialyzed into 10 μM EDTA to remove Mg2+, it binds MLS000544460 with a higher affinity (Kd=0.80 μM), indicating that this class of compounds does not require Mg2+ for its interaction with the Eya2 ED[1].

Molecular Weight

341.36

Formula

C₁₇H₁₂FN₃O₂S

CAS No.

352336-36-8

SMILES

FC1=CC=CC(C(N/N=C/C2=CC=C(SC3=CC=CC=N3)O2)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MLS000544460MLS 000544460MLS-000544460PhosphatasereversibleEya2phosphatasecellmigrationanti-cancerInhibitorinhibitorinhibit

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MLS000544460
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