2. GPCR/G Protein
  3. Apelin Receptor (APJ)
  4. MM 54

MM 54 (compound 5) is a competitive antagonist at APJ, with an IC50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

MM 54 Chemical Structure

MM 54 Chemical Structure

CAS No. : 1313027-43-8

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1 mg USD 300 In-stock
5 mg USD 840 In-stock
10 mg USD 1340 In-stock
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Based on 1 publication(s) in Google Scholar

MM 54 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

MM 54 (compound 5) is a competitive antagonist at APJ, with an IC50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation[1][2].

In Vitro

MM 54 inhibits more than 95% of apelin binding to APLNR at the dose of 10 µM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MM 54 Related Antibodies
In Vivo

MM 54 (2 mg/kg, ip, bi-weekly for 4 weeks) possesses anti-tumor activity in glioblastoma models with no obvious toxicity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tumour-bearing nude-mice[2].
Dosage: 2 mg/kg.
Administration: Intraperitoneal injection, bi-weekly for 4 weeks.
Result: Reduced tumor progression (glioblastoma).
Molecular Weight

1737.16

Formula

C70H121N29O15S4
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Cys-Arg-Pro-Arg-Leu-Cys-Lys-His-Cys-Arg-Pro-Arg-Leu-Cys (Disulfide bridge:Cys1-Cys6; Cys9-Cys14)
Sequence Shortening

CRPRLCKHCRPRLC (Disulfide bridge:Cys1-Cys6; Cys9-Cys14)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (57.57 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5757 mL 2.8783 mL 5.7565 mL
5 mM 0.1151 mL 0.5757 mL 1.1513 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.5757 mL 2.8783 mL 5.7565 mL 14.3913 mL
5 mM 0.1151 mL 0.5757 mL 1.1513 mL 2.8783 mL
10 mM 0.0576 mL 0.2878 mL 0.5757 mL 1.4391 mL
15 mM 0.0384 mL 0.1919 mL 0.3838 mL 0.9594 mL
20 mM 0.0288 mL 0.1439 mL 0.2878 mL 0.7196 mL
25 mM 0.0230 mL 0.1151 mL 0.2303 mL 0.5757 mL
30 mM 0.0192 mL 0.0959 mL 0.1919 mL 0.4797 mL
40 mM 0.0144 mL 0.0720 mL 0.1439 mL 0.3598 mL
50 mM 0.0115 mL 0.0576 mL 0.1151 mL 0.2878 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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MM 54 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MM 541313027-43-8MM54MM-54Apelin Receptor (APJ)GlioblastomaGSCapelinAPLNRInhibitorinhibitorinhibit

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