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Cat. No.: HY-162853

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Mtb-IN-8

Mtb-IN-8 (compound 5jb) is an orally active inhibitor of Mycobacterium tuberculosis (Mtb) with MIC values of 0.03 μg/mL for H37Rv and 0.125-0.06 μg/mL for MDR-Mtb, respectively.

For research use only. We do not sell to patients.

CAS No.: 2549199-96-2
Formula: C₁₇H₁₈N₄O₅S
Molecular Weight:390.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Mtb-IN-8 Chemical Structure

CAS No.: 2549199-96-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Mtb-IN-8 (compound 5jb) is an orally active inhibitor of Mycobacterium tuberculosis (Mtb) with MIC values of 0.03 μg/mL for H37Rv and 0.125-0.06 μg/mL for MDR-Mtb, respectively^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HK-2	IC₅₀	41.11 μg/mL Compound: 5jb	Cytotoxicity against HK-2 cells incubated for 48 hrs by CCK8 assay Cytotoxicity against HK-2 cells incubated for 48 hrs by CCK8 assay	[PMID: 39166949]
Vero	IC₅₀	>64 μg/mL Compound: 5jb	Cytotoxicity against african green monkey Vero cells incubated for 48 hrs by CCK8 assay Cytotoxicity against african green monkey Vero cells incubated for 48 hrs by CCK8 assay	[PMID: 39166949]

Chemical Information

CAS No. 2549199-96-2
Molecular Weight 390.41
Formula C₁₇H₁₈N₄O₅S
SMILES

COC1=CC=C([C@@H]2C(C(NC(SCCC)=N3)=O)=C3NC(C2)=O)C([N+]([O-])=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sun L,et al. Design, Synthesis, and Evaluation of the Antitubercular Activity of 5-Phenyl Substituted-5, 6-dihydropyrido[2, 3-d]pyrimidine-4, 7(3H, 8H)-dione Compounds. J Med Chem. 2024 Sep 12;67(17):14927-14945. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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